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局部烟酰胺可增强不同面部位置角蛋白细胞包膜的疏水性和弹性。

Topical niacinamide enhances hydrophobicity and resilience of corneocyte envelopes on different facial locations.

机构信息

DSM Nutritional Products Ltd, Wurmisweg 576, 4303 Kaiseraugst, Switzerland.

UCL School of Pharmacy, 29-39 Brunswick Square, WC1N 1AX, London, UK.

出版信息

Int J Cosmet Sci. 2020 Dec;42(6):632-636. doi: 10.1111/ics.12666.

DOI:10.1111/ics.12666
PMID:33038007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8365309/
Abstract

Age-related differences in maturation parameters of corneocyte envelopes (size, hydrophobicity and rigidity) were examined at several facial test sites in young and old female Caucasians. In addition, the effect of topically applied niacinamide on these parameters was evaluated in a 4-week placebo-controlled study.

摘要

研究了年轻和老年白种女性面部几个测试部位的角质细胞包膜（大小、疏水性和刚性）成熟参数的年龄相关差异。此外，还在为期 4 周的安慰剂对照研究中评估了局部应用烟酰胺对这些参数的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15e0/8365309/e114d1cbbb9a/ICS-42-632-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15e0/8365309/07e4969dd304/ICS-42-632-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15e0/8365309/3b102dec1747/ICS-42-632-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15e0/8365309/91c65f25415e/ICS-42-632-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15e0/8365309/e114d1cbbb9a/ICS-42-632-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15e0/8365309/07e4969dd304/ICS-42-632-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15e0/8365309/3b102dec1747/ICS-42-632-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15e0/8365309/91c65f25415e/ICS-42-632-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15e0/8365309/e114d1cbbb9a/ICS-42-632-g005.jpg

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Sci Rep. 2020 Jun 15;10(1):9626. doi: 10.1038/s41598-020-66723-1.
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SDR9C7 plays an essential role in skin barrier function by dehydrogenating acylceramide for covalent attachment to proteins.SDR9C7 通过使酰基神经酰胺脱氢从而将其共价连接到蛋白质上，在皮肤屏障功能中发挥重要作用。
J Dermatol Sci. 2020 May;98(2):82-87. doi: 10.1016/j.jdermsci.2020.03.005. Epub 2020 Mar 28.
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Med Gas Res. 2022 Jan-Mar;12(1):24-27. doi: 10.4103/2045-9912.320704.
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