新生儿海马体体积调节了早期产后丰富环境对认知发育的影响。
Neonatal hippocampal volume moderates the effects of early postnatal enrichment on cognitive development.
机构信息
Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Medical Psychology, Berlin, Germany.
Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Medical Psychology, Berlin, Germany; Development, Health, and Disease Research Program, University of California, Irvine, Orange, CA, USA.
出版信息
Dev Cogn Neurosci. 2020 Oct;45:100820. doi: 10.1016/j.dcn.2020.100820. Epub 2020 Jul 4.
Environmental enrichment, particularly during the early life phases of enhanced neuroplasticity, can stimulate cognitive development. However, individuals exhibit considerable variation in their response to environmental enrichment. Recent evidence suggests that certain neurophenotypes such as hippocampal size may index inter-individual differences in sensitivity to environmental conditions. We conducted a prospective, longitudinal investigation in a cohort of 75 mother-child dyads to investigate whether neonatal hippocampal volume moderates the effects of the postnatal environment on cognitive development. Newborn hippocampal volume was quantified shortly after birth (26.2 ± 12.5 days) by structural MRI. Measures of infant environmental enrichment (assessed by the IT-HOME) and cognitive state (assessed by the Bayley-III) were obtained at 6 months of age (6.09 ± 1.43 months). The interaction between neonatal hippocampal volume and enrichment predicted infant cognitive development (b = 0.01, 95 % CI [0.00, 0.02], t = 2.08, p = .04), suggesting that exposure to a stimulating environment had a larger beneficial effect on cognitive outcomes among infants with a larger hippocampus as neonates. Our findings suggest that the effects of the postnatal environment on infant cognitive development are conditioned, in part, upon characteristics of the newborn brain, and that newborn hippocampal volume is a candidate neurophenotype in this context.
环境丰富化，特别是在增强神经可塑性的早期生命阶段，可以刺激认知发展。然而，个体对环境丰富化的反应存在很大差异。最近的证据表明，某些神经表型，如海马体大小，可能可以反映出对环境条件的敏感性的个体差异。我们在一个 75 对母婴队列中进行了一项前瞻性、纵向研究，以调查新生儿海马体体积是否调节了后天环境对认知发展的影响。通过结构 MRI，在新生儿出生后不久（26.2±12.5 天）对海马体体积进行了量化。婴儿环境丰富度（通过 IT-HOME 评估）和认知状态（通过 Bayley-III 评估）的测量值在 6 个月龄时（6.09±1.43 个月）获得。新生儿海马体体积和丰富度之间的相互作用预测了婴儿的认知发展（b=0.01，95%CI[0.00，0.02]，t=2.08，p=0.04），这表明在新生儿时期海马体较大的婴儿中，暴露于刺激环境对认知结果有更大的有益影响。我们的研究结果表明，后天环境对婴儿认知发展的影响在一定程度上取决于新生儿大脑的特征，并且新生儿海马体体积是该背景下的一个候选神经表型。
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