Perm Federal Research Center, Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences, Perm, 614081, Russia.
Biochemistry (Mosc). 2020 Aug;85(8):839-853. doi: 10.1134/S0006297920080015.
The work is focused on physiological role of the hormone kisspeptin produced by neurons of the hypothalamus anterior zone, which is a key regulator of reproduction processes. Role of the hormone in transmission of information on metabolic activity and induction of the secretion of gonadotropin-releasing hormone (GnRH) by the hypothalamus that determines gestation processes involving fertilization, placentation, fetal development, and child birth is considered. The literature data on molecular mechanisms and effects of kisspeptin on reproductive system including puberty initiation are summarized and analyzed. In addition, attention is paid to hormone-mediated changes in the cardiovascular system in pregnant women. For the first time, the review examines the effect of kisspeptin on functional activity of immune system cells presenting molecular mechanisms of the hormone signal transduction on the level of lymphoid cells that lead to the immune tolerance induction. In conclusion, a conceptual model is presented that determines the role of kisspeptin as an integrator of reproductive and immune functions during pregnancy.
这项工作集中在由下丘脑前区神经元产生的激素 kisspeptin 的生理作用上，它是生殖过程的关键调节剂。考虑到激素在代谢活动信息传递和诱导下丘脑促性腺激素释放激素 (GnRH) 分泌中的作用，后者决定了涉及受精、胎盘形成、胎儿发育和分娩的妊娠过程。总结和分析了关于 kisspeptin 对生殖系统包括青春期启动的分子机制和影响的文献数据。此外，还关注了激素介导的孕妇心血管系统变化。本文首次研究了 kisspeptin 对免疫细胞功能活性的影响，提出了激素信号转导的分子机制在导致免疫耐受诱导的淋巴细胞水平上的作用。总之，提出了一个概念模型，确定了 kisspeptin 在妊娠期间作为生殖和免疫功能整合者的作用。
