Department of Pharmaceutics, Arvind Gavali College of Pharmacy, Satara, Shivaji University, Satara-415004, India.
Department of Pharmaceutical Chemistry, Arvind Gavali College of Pharmacy, Satara, Shivaji University, Satara- 415004, India.
Curr Drug Targets. 2021;22(4):443-462. doi: 10.2174/1389450121999201012201455.
Cancer is the most ruinous disease globally. Natural products have impressive characteristics, such as exceptional chemical versatility, chemical and biological properties of macromolecular specificity and less toxicity which make them good leads in finding novel drugs. The phytochemicals not only help to prevent but also treat chronic cancerous conditions. The present review attempts to put forth some selected anticancer phytochemicals that had reported omics characteristic and specifically suppressed cancer with in vitro and in vivo activity. Certain issues pertaining to anticancer phytochemicals like delivery to target site in the body and achieving controlled release in order to prevent overdoses have been a major concern for medical researchers worldwide. The most conventional chemotherapy protocols for the treatment of cancer lead to adverse effects that limit biological efficacy and compromise patient outcomes. In order to defeat incompetency of current and upcoming natural anticancer agents and to attain targeted drug delivery with good efficacy and fewer side effects, there is a special focus on novel nanostructured particles and nano approaches consisting of carrier system. Recent studies have led to the discovery of mesoporous and nanoporous drug delivery mechanisms, such as inorganic or organic-based nanosponges. The metal based inorganic systems have exhibited toxicity and non-biodegradable character in vivo. As a result of problems related to inorganic systems, major shift of research from inorganic to organic nanosystems has occurred. About decades ago, researchers developed organic nanosponges to control the limitation of drug delivery and cancer therapies. This review article discusses the development and application of nanosponges encapsulated phytochemicals for cancer therapy.
癌症是全球最具毁灭性的疾病。天然产物具有令人印象深刻的特点，例如出色的化学多功能性、大分子特异性的化学和生物性质以及较低的毒性，这使它们成为寻找新型药物的良好先导化合物。植物化学物质不仅有助于预防，还可以治疗慢性癌症。本综述试图提出一些已报道具有组学特征的抗癌植物化学物质，并特别通过体外和体内活性抑制癌症。某些与抗癌植物化学物质相关的问题，如递送到体内的靶部位以及实现控制释放以防止过量，一直是全球医学研究人员关注的主要问题。目前用于治疗癌症的最常规化疗方案会导致不良反应，从而限制生物疗效并影响患者的治疗效果。为了克服当前和即将出现的天然抗癌药物的无效性，并实现具有良好疗效和较少副作用的靶向药物递送，人们特别关注新型纳米结构颗粒和纳米方法，包括载体系统。最近的研究导致了介孔和纳米孔药物递送机制的发现，例如无机或有机纳米海绵。基于金属的无机系统在体内表现出毒性和不可生物降解性。由于与无机系统相关的问题，研究重点已经从无机系统向有机纳米系统发生了重大转移。大约在几十年前，研究人员开发了有机纳米海绵来控制药物递送和癌症治疗的局限性。本文综述了包封植物化学物质的纳米海绵在癌症治疗中的开发和应用。
