基于氢原子转移光催化剂的醛的光介导二氟甲硫基化反应
Light-Mediated Difluoromethylthiolation of Aldehydes with a Hydrogen Atom Transfer Photocatalyst.
作者信息
Dong Jianyang, Yue Fuyang, Wang Xiaochen, Song Hongjian, Liu Yuxiu, Wang Qingmin
机构信息
State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, People's Republic of China.
Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, People's Republic of China.
出版信息
Org Lett. 2020 Nov 6;22(21):8272-8277. doi: 10.1021/acs.orglett.0c02902. Epub 2020 Oct 13.
A mild general method for difluoromethylthiolation of aldehydes with PhSOSCFH and a decatungstate photocatalyst under redox-neutral conditions has been developed. This reaction is highly efficient, scalable, and oxidant-free. The broad substrate scope and excellent functional group tolerance of the reaction make it suitable for generating libraries of difluoromethyl thioesters. We demonstrated the utility and sustainability of the method by synthesizing several structurally complex difluoromethyl thioesters.
已开发出一种温和的通用方法，用于在氧化还原中性条件下，使用苯亚磺酰二氟甲烷（PhSOSCFH）和十钨酸盐光催化剂对醛进行二氟甲基硫醇化反应。该反应高效、可扩展且无需氧化剂。该反应广泛的底物范围和出色的官能团耐受性使其适用于生成二氟甲基硫酯文库。我们通过合成几种结构复杂的二氟甲基硫酯证明了该方法的实用性和可持续性。
Zotero 插件