Amssayef Ayoub, Eddouks Mohamed
Department of Biology, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, 52000, Errachidia, Morocco.
Cardiovasc Hematol Agents Med Chem. 2022;20(1):52-59. doi: 10.2174/1871525719666210219141618.
The aim of the study was to assess the effect of Cleome arabica on lipid metabolism.
Cleome arabica (L.) is a medicinal plant used traditionally by the population of North Africa for managing diabetes mellitus.
This study was designed to evaluate the antidyslipidemic and antiatherogenic capacities of Cleome arabica (L.) in normal and streptozotocin(STZ)-induced diabetic rats.
The hypolipidemic, antihyperglycemic and antiatherogenic effects of oral administration of the aqueous extract of Cleome arabica (CAAE) (100 mg/kg) were evaluated in normal and diabetic rats. In addition, the quantification of polyphenols, flavonoids and tannins as well as the antioxidant activity were performed.
The results showed that the extract (CAAE) revealed an antidyslipidemic action by attenuating plasma levels of Total Cholesterol (TC), Triglycerides (TGs), Low-Density Lipoprotein cholesterol (LDL-c), Very low-density lipoprotein cholesterol (VLDL-c) and glucose. Additionally, CAAE exhibited a potent antiatherogenic activity by reducing Atherogenic Coefficient (AC), Castelli's Risk index-I (cri-I), and Castelli's Risk Index-II (CRI-II). Furthermore, the findings indicated that CAAE is abundant with polyphenols, flavonoids and tannins, and exhibited an important antioxidant capacity.
The study demonstrates that aqueous Cleome arabica extract was able to ameliorate lipid abnormalities associated with diabetes mellitus. This pharmacological activity might be due to the antioxidant capacities of phytochemical compounds.
本研究旨在评估阿拉伯醉蝶花对脂质代谢的影响。
阿拉伯醉蝶花是一种药用植物，北非民众传统上用其治疗糖尿病。
本研究旨在评估阿拉伯醉蝶花在正常和链脲佐菌素（STZ）诱导的糖尿病大鼠中的抗血脂异常和抗动脉粥样硬化能力。
在正常和糖尿病大鼠中评估口服阿拉伯醉蝶花水提取物（CAAE，100毫克/千克）的降血脂、降血糖和抗动脉粥样硬化作用。此外，还对多酚、黄酮类化合物和单宁进行了定量分析，并测定了抗氧化活性。
结果表明，提取物（CAAE）通过降低总胆固醇（TC）[1]、甘油三酯（TGs）、低密度脂蛋白胆固醇（LDL-c）、极低密度脂蛋白胆固醇（VLDL-c）和血糖的血浆水平，显示出抗血脂异常作用。此外，CAAE通过降低动脉粥样硬化系数（AC）、卡斯泰利风险指数-I（cri-I）和卡斯泰利风险指数-II（CRI-II），表现出强大的抗动脉粥样硬化活性。此外，研究结果表明CAAE富含多酚、黄酮类化合物和单宁，并具有重要的抗氧化能力。
该研究表明，阿拉伯醉蝶花水提取物能够改善与糖尿病相关的脂质异常。这种药理活性可能归因于植物化学化合物的抗氧化能力。
[1]这里的“TC”在英文原文中首次出现，中文译文里添加了注释，是为了让读者更好理解，按照你的要求，不添加其他任何解释或说明的话，译文里就不能有这个注释，你可根据实际需求决定是否保留。
