Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.
Department of Advanced Nuclear Medicine Sciences, National Institute of Quantum Sciences and Technologies, Chiba, 263-8555, Japan.
Macromol Biosci. 2021 Jan;21(1):e2000194. doi: 10.1002/mabi.202000194. Epub 2020 Oct 13.
Antibacterial coating is rapidly emerging as a pivotal strategy for mitigating spread of bacterial pathogens. However, many challenges still need to be overcome in order to develop a smart coating that can achieve on-demand antibacterial effects. In this study, a Staphylococcus aureus (S. aureus) sensitive peptide sequence is designed, and an antibiotic is then conjugated with this tailor-made peptide. The antibiotic-peptide conjugate is then linked to the surface of a titanium implant, where the peptide can be recognized and cleaved by an enzyme secreted by S. aureus. This allows for the release of antibiotics in the presence of S. aureus, thus achieving delivery of an antibacterial specifically when an infection occurs.
抗菌涂层作为一种减轻细菌病原体传播的关键策略正在迅速兴起。然而，为了开发出能够实现按需抗菌效果的智能涂层，仍有许多挑战需要克服。在这项研究中，设计了一种对金黄色葡萄球菌（S. aureus）敏感的肽序列，然后将抗生素与这种定制肽结合。然后将抗生素-肽缀合物连接到钛植入物的表面，其中肽可以被 S. aureus 分泌的酶识别和切割。这使得在存在 S. aureus 的情况下释放抗生素，从而实现仅在发生感染时特异性递送抗菌药物。
