Eliasi Ulemu L, Sebola Dikeledi, Oguttu James W, Qekwana Daniel N
Section Veterinary Public Health, Department of Paraclinical Science, Faculty of Veterinary Sciences, University of Pretoria, Pretoria.
J S Afr Vet Assoc. 2020 Sep 22;91(0):e1-e6. doi: 10.4102/jsava.v91i0.2052.
Although Pseudomonas aeruginosa (P. aeruginosa) can infect both animals and humans, there is a paucity of veterinary studies on antimicrobial resistance of P. aeruginosa in South Africa. Secondary data of canine clinical cases presented at the hospital from January 2007 to December 2013 was used. The following information was recorded: type of sample, the date of sampling and the antimicrobial susceptibility results. Frequencies, proportions and their 95% confidence intervals were calculated for all the categorical variables. In total, 155 P. aeruginosa isolates were identified and included in this study. All the isolates were resistant to at least one antimicrobial (AMR), while 92% were multi-drug resistant (MDR). Most isolates were resistant to lincomycin (98%), penicillin-G (96%), orbifloxacin (90%), trimethoprim-sulfamethoxazole (90%) and doxycycline (87%). A low proportion of isolates was resistant to imipenem (6%), tobramycin (12%), amikacin (16%) and gentamicin (18%). A high proportion of MDR-P. aeruginosa isolates was resistant to amoxycillin-clavulanic acid (99%), tylosin (99%), chloramphenicol (97%) and doxycycline (96%). Few (6%) of MDR-P. aeruginosa isolates were resistant to imipenem. Pseudomonas aeruginosa was associated with infections of various organ systems in this study. All P. aeruginosa isolates of P. aeruginosa exhibited resistance to β-lactams, fluoroquinolones and lincosamides. Clinicians at the hospital in question should consider these findings when treating infections associated with P. aeruginosa.
尽管铜绿假单胞菌可感染动物和人类，但南非关于铜绿假单胞菌耐药性的兽医研究较少。本研究使用了2007年1月至2013年12月期间该医院犬类临床病例的二级数据。记录了以下信息：样本类型、采样日期和药敏结果。计算了所有分类变量的频率、比例及其95%置信区间。本研究共鉴定并纳入了155株铜绿假单胞菌分离株。所有分离株均对至少一种抗菌药物耐药（AMR），而92%为多重耐药（MDR）。大多数分离株对林可霉素（98%）、青霉素G（96%）、奥比沙星（90%）、甲氧苄啶-磺胺甲恶唑（90%）和强力霉素（87%）耐药。低比例的分离株对亚胺培南（6%）、妥布霉素（12%）、阿米卡星（16%）和庆大霉素（18%）耐药。高比例的多重耐药铜绿假单胞菌分离株对阿莫西林-克拉维酸（99%）、泰乐菌素（99%）、氯霉素（97%）和强力霉素（96%）耐药。很少（6%）的多重耐药铜绿假单胞菌分离株对亚胺培南耐药。在本研究中，铜绿假单胞菌与各种器官系统的感染有关。所有铜绿假单胞菌分离株均对β-内酰胺类、氟喹诺酮类和林可酰胺类耐药。该医院的临床医生在治疗与铜绿假单胞菌相关的感染时应考虑这些发现。
