Histology and Embryology Department, Faculty of Medicine, Istinye University, Istanbul, Turkey; Center for Stem Cell and Tissue Engineering Research and Practice, Istinye University, Istanbul, Turkey.
Histology and Embryology Department, Faculty of Medicine, Istinye University, Istanbul, Turkey; Center for Stem Cell and Tissue Engineering Research and Practice, Istinye University, Istanbul, Turkey; Center for Regenerative Medicine and Stem Cell Research and Manufacturing, Liv Hospital, Istanbul, Turkey.
Acta Histochem. 2020 Dec;122(8):151634. doi: 10.1016/j.acthis.2020.151634. Epub 2020 Oct 12.
Almost from all organs, both mesenchymal stromal cells and fibroblasts can be isolated. Mesenchymal stromal cells (MSCs) are the most preferred cellular therapeutic agents with the regenerative potential, and fibroblasts are one of the most abundant cell types with the ability to maintain homeostasis. Because of the promising properties of MSCs, they have been well studied and their differentiation potentials, immunomodulatory potentials, gene expression profiles are identified. It has been observed that fibroblasts and mesenchymal stromal cells have similar morphology, gene expression patterns, surface markers, proliferation, differentiation, and immunomodulatory capacities. Thus, it is hard to distinguish these two cell types. Epigenetic signatures, i.e., methylation patterns of cells, are the only usable promising difference between them. Such significant similarities show that these two cells may be related to each other.
几乎所有器官都可以分离出间充质基质细胞和成纤维细胞。间充质基质细胞（MSCs）是最具再生潜能的首选细胞治疗剂，成纤维细胞是维持内稳态能力最强的细胞类型之一。由于 MSCs 的良好特性，它们已被广泛研究，其分化潜能、免疫调节潜能和基因表达谱已被确定。已经观察到成纤维细胞和间充质基质细胞具有相似的形态、基因表达模式、表面标记物、增殖、分化和免疫调节能力。因此，很难区分这两种细胞类型。表观遗传特征，即细胞的甲基化模式，是它们之间唯一可用的有希望的差异。这些显著的相似性表明这两种细胞可能彼此相关。
