Graduate Department of Health Sciences and Technologies, University of Brasilia (UnB), Brasilia, Federal District, Brazil.
Physical Education Department, University Center of Brasilia, Brasilia, Federal District, Brazil.
Clin Interv Aging. 2020 Sep 18;15:1691-1700. doi: 10.2147/CIA.S252589. eCollection 2020.
Analyze the influence between the components of metabolic syndrome and the independent risk for cardiovascular disease (CVD) in the elderly.
A descriptive cross-sectional study was carried out with 205 older adults from a primary healthcare unit of the Federal District, Brazil. The cardiovascular risk was determined by the Framingham Risk Score (FRS). The National Cholesterol Evaluation Program for Adult Treatment Panel III 2001 (NCEP-ATP III) criteria were considered to analyze metabolic syndrome (MS) diagnoses.
There was a strong association between MS and high cardiovascular risk (OR = 8.86). The univariate analysis main findings revealed that male gender, diabetes, smoking habit, systolic blood pressure, HDL level, high blood glucose, glycated hemoglobin, and LDL level were associated with high cardiovascular risk. FRS increases significantly with the presence of four or more MS components (by 30%, if 4 components are present, and by 40%, if 5 components) when compared with the presence of three or fewer components (P <0.001). A logistic regression analysis of high-risk predictors was described to reduce the effects of confounding and bias factors.
The identification of MS associated with high FRS values represents a cascading of adverse effects on the population's aging process.
分析代谢综合征各成分与老年人心血管疾病（CVD）独立风险之间的关系。
巴西联邦区某初级保健单位进行了一项描述性横断面研究，共纳入 205 名老年人。心血管风险由弗雷明汉风险评分（FRS）确定。采用美国国家胆固醇教育计划成人治疗专家组第三次报告（NCEP-ATP III）2001 年标准分析代谢综合征（MS）诊断。
MS 与高心血管风险之间存在强相关性（OR=8.86）。单变量分析的主要发现表明，男性、糖尿病、吸烟习惯、收缩压、HDL 水平、高血糖、糖化血红蛋白和 LDL 水平与高心血管风险相关。与存在 3 个或更少 MS 成分相比，存在 4 个或更多 MS 成分（如果存在 4 个成分，则增加 30%，如果存在 5 个成分，则增加 40%）时，FRS 显著增加（P<0.001）。为了减少混杂和偏倚因素的影响，对高风险预测因子进行了逻辑回归分析。
MS 与高 FRS 值相关联，代表了人口老龄化过程中不良影响的级联。
