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氧化铈纳米颗粒在骨科生物医学应用中的研究进展。

The Advances of Ceria Nanoparticles for Biomedical Applications in Orthopaedics.

机构信息

Department of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun 130041, People's Republic of China.

出版信息

Int J Nanomedicine. 2020 Sep 29;15:7199-7214. doi: 10.2147/IJN.S270229. eCollection 2020.

DOI:10.2147/IJN.S270229
PMID:33061376
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7535115/
Abstract

The ongoing biomedical nanotechnology has intrigued increasingly intense interests in cerium oxide nanoparticles, ceria nanoparticles or nano-ceria (CeO-NPs). Their remarkable vacancy-oxygen defect (VO) facilitates the redox process and catalytic activity. The verification has illustrated that CeO-NPs, a nanozyme based on inorganic nanoparticles, can achieve the anti-inflammatory effect, cancer resistance, and angiogenesis. Also, they can well complement other materials in tissue engineering (TE). Pertinent to the properties of CeO-NPs and the pragmatic biosynthesis methods, this review will emphasize the recent application of CeO-NPs to orthopedic biomedicine, in particular, the bone tissue engineering (BTE). The presentation, assessment, and outlook of the orthopedic potential and shortcomings of CeO-NPs in this review expect to provide reference values for the future research and development of therapeutic agents based on CeO-NPs.

摘要

正在进行的生物医学纳米技术引起了人们对氧化铈纳米粒子、氧化铈纳米粒子或纳米氧化铈（CeO-NPs）越来越浓厚的兴趣。它们显著的空位-氧缺陷（VO）促进了氧化还原过程和催化活性。验证表明，CeO-NPs 作为一种基于无机纳米粒子的纳米酶，可实现抗炎、抗癌和血管生成的效果。此外，它们还可以很好地与组织工程（TE）中的其他材料互补。鉴于 CeO-NPs 的特性和实用的生物合成方法，本综述将重点介绍 CeO-NPs 在骨科生物医学中的最新应用，特别是在骨组织工程（BTE）中的应用。本综述对 CeO-NPs 在骨科方面的潜力和缺点进行了介绍、评估和展望，以期为基于 CeO-NPs 的治疗剂的未来研究和开发提供参考价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1300/7535115/2379c65e2ea7/IJN-15-7199-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1300/7535115/42023b35988e/IJN-15-7199-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1300/7535115/a5fb0b62b50e/IJN-15-7199-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1300/7535115/060597c8a57c/IJN-15-7199-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1300/7535115/2379c65e2ea7/IJN-15-7199-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1300/7535115/42023b35988e/IJN-15-7199-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1300/7535115/a5fb0b62b50e/IJN-15-7199-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1300/7535115/060597c8a57c/IJN-15-7199-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1300/7535115/2379c65e2ea7/IJN-15-7199-g0004.jpg

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