PD-L1 表达水平与胰腺癌中的免疫应答呈正相关。
PD-L1 Expression Level Displays a Positive Correlation with Immune Response in Pancreatic Cancer.
机构信息
Department of Hepatobiliary and Pancreatic Surgery, First Hospital of China Medical University, Shenyang, Liaoning 110001, China.
Department of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning 110122, China.
出版信息
Dis Markers. 2020 Sep 25;2020:8843146. doi: 10.1155/2020/8843146. eCollection 2020.
The expression of PD-L1 could be a novel biomarker which predicts that patients are more likely to respond to immunotherapy. Our study investigated the relationship among clinicopathological characteristics, prognosis, PD-L1 expression levels, and FOXP3 Treg infiltration. In addition, the relationship among clinicopathological characteristics, prognosis, PD-L1 expression levels, and FOXP3 Treg infiltration was explored. Furthermore, the relationship between PD-L1 expression and FOXP3 Treg infiltration was examined. We found that 41.3% of pancreatic cancer patients had PD-L1-positive staining; both PD-L1 expression levels and FOXP3 Treg infiltration were significantly associated with depth of invasion, lymph node metastasis, distant metastasis, and pTNM. In addition, PD-L1 expression and FOXP3 Treg infiltration also could be prognostic biomarkers for pancreatic cancer.
PD-L1 的表达可能是一种新的生物标志物，可预测患者更有可能对免疫治疗产生反应。我们的研究调查了临床病理特征、预后、PD-L1 表达水平和 FOXP3+Treg 浸润之间的关系。此外，还探讨了临床病理特征、预后、PD-L1 表达水平和 FOXP3+Treg 浸润之间的关系。此外，还研究了 PD-L1 表达与 FOXP3+Treg 浸润之间的关系。结果发现，41.3%的胰腺癌患者存在 PD-L1 阳性染色；PD-L1 表达水平和 FOXP3+Treg 浸润均与浸润深度、淋巴结转移、远处转移和 pTNM 显著相关。此外，PD-L1 表达和 FOXP3+Treg 浸润也可能是胰腺癌的预后生物标志物。
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