2019冠状病毒病的分子诊断
Molecular Diagnosis of Coronavirus Disease 2019.
作者信息
Dos Santos Claudia C, Zehnbauer Barbara A, Trahtemberg Uriel, Marshall John
机构信息
Keenan Research Center for Biomedical Research, Unity Health Toronto, Toronto, ON, Canada.
Interdepartmental Division of Critical Care and Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.
出版信息
Crit Care Explor. 2020 Sep 17;2(9):e0184. doi: 10.1097/CCE.0000000000000184. eCollection 2020 Sep.
OBJECTIVES
To review molecular diagnostics for coronavirus disease 2019. The world is in the midst of a coronavirus disease 2019 pandemic. Containing the spread of the severe acute respiratory distress coronavirus is critical. Instrumental to the future success is the ability to reliably and reproducibly detect this inciting pathogen to inform public health containment policies and treatment decisions.
DATA SOURCES
Molecular diagnostics focusing on molecular detection methodologies for detection of the virus and the presence of the disease.
STUDY SELECTION
Narrative review.
DATA EXTRACTION
Literature, PubMed, Scopus, and official government documents.
DATA SYNTHESIS
Diagnosing severe acute respiratory syndrome coronavirus is done through real-time reverse transcriptase-polymerase chain reaction tests, cell culture, and serology. For patients, diagnostics are an integral part of a full medical history, physical examinations, blood tests, and diagnostic imaging.
CONCLUSIONS
Here, we review current approaches to the molecular diagnosis of coronavirus disease 2019.
目标
回顾2019冠状病毒病的分子诊断方法。全球正处于2019冠状病毒病大流行之中。遏制严重急性呼吸综合征冠状病毒的传播至关重要。未来成功的关键在于能够可靠且可重复地检测出这种致病病原体，以为公共卫生防控政策和治疗决策提供依据。
数据来源
聚焦于病毒检测和疾病存在的分子检测方法的分子诊断。
研究选择
叙述性综述。
数据提取
文献、PubMed、Scopus和官方政府文件。
数据综合
通过实时逆转录聚合酶链反应检测、细胞培养和血清学来诊断严重急性呼吸综合征冠状病毒。对于患者而言，诊断是完整病史、体格检查、血液检测和诊断性成像的一个组成部分。
结论
在此，我们回顾了2019冠状病毒病分子诊断的当前方法。
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