Yozgat Bozok University, Faculty of Medicine, Department of Obstetrics and Gynecology, Yozgat, Turkey.
Yozgat Bozok University, Faculty of Medicine, Department of Public Health, Yozgat, Turkey.
Z Geburtshilfe Neonatol. 2020 Dec;224(6):339-347. doi: 10.1055/a-1263-1698. Epub 2020 Oct 15.
Intensive research has been conducted on the effects of toxic and trace elements on pregnancy. Previous studies indicated a possible relationship between placental levels of these elements and first-trimester abortion; however, their effects on the further gestational weeks are not clear. This study aimed to investigate the effect of changes in the levels of placental trace and toxic elements on second-trimester abortion.
The patient group consisted of 30 women with missed abortion. The control group comprised 60 healthy term and singleton pregnant women who gave birth. Placental samples were obtained from the patients and the healthy controls, and the concentrations of placental elements were measured using inductively coupled plasma mass spectrometry.
In the abortion group, placental arsenic, cadmium, mercury, lead, antimony, tin, cobalt, manganese, and selenium levels were significantly higher than those of the control group (p<0.05). Antimony was determined as an independent predictor with an odds ratio of 6.1 in toxic elements (p=0.025), and selenium was determined as an independent predictor with an odds ratio of 2.3 in trace elements (p=0.015).
The changes in trace element and toxic element levels, especially an increase in antimony and selenium, in placental tissue due to environmental exposure may play an important role in second-trimester abortion.
对有毒微量元素对妊娠的影响进行了深入研究。先前的研究表明，这些元素在胎盘内的水平可能与早期流产之间存在一定的关系；然而，它们对妊娠后期的影响尚不清楚。本研究旨在探讨胎盘内痕量和有毒元素水平的变化对中期流产的影响。
患者组包括 30 名稽留流产患者。对照组由 60 名健康足月单胎孕妇组成，这些孕妇均顺利分娩。从患者和健康对照组中采集胎盘样本，并使用电感耦合等离子体质谱法测量胎盘元素浓度。
在流产组中，胎盘砷、镉、汞、铅、锑、锡、钴、锰和硒的水平明显高于对照组（p<0.05）。锑被确定为有毒元素的独立预测因子，其比值比为 6.1（p=0.025），而硒被确定为痕量元素的独立预测因子，其比值比为 2.3（p=0.015）。
由于环境暴露导致胎盘组织中痕量元素和有毒元素水平的变化，特别是锑和硒的增加，可能在中期流产中发挥重要作用。
