Lutz J C, Nugent K M
Mycopathologia. 1987 Jul;99(1):21-4. doi: 10.1007/BF00436676.
Antifungal agents alter the function and morphology of Candida cell membranes and cell walls. We observed that brief (30 minute) exposure to either amphotericin B or clotrimazole inhibited the agglutination of Candida blastoconidia by murine bronchoalveolar lavage fluid. This inhibition required continuous drug presence. Neither amphotericin nor clotrimazole inhibited Candida agglutination by concanavalin A or pooled human serum. These results demonstrate that antifungal drugs can produce rapid changes in the surface characteristics of some fungi.
抗真菌药物会改变念珠菌细胞膜和细胞壁的功能及形态。我们观察到，将念珠菌芽生孢子暴露于两性霉素B或克霉唑中30分钟，会抑制其被小鼠支气管肺泡灌洗液凝集。这种抑制作用需要药物持续存在。两性霉素和克霉唑均不会抑制伴刀豆球蛋白A或混合人血清对念珠菌的凝集作用。这些结果表明，抗真菌药物可使某些真菌的表面特征迅速发生变化。
