Department of Neurosurgery, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, 610041, Sichuan, China.
West China School of Medicine, Sichuan University, Chengdu, 610041, China.
J Neurooncol. 2020 Sep;149(3):543-553. doi: 10.1007/s11060-020-03649-8. Epub 2020 Oct 16.
The purpose of this article was to study the characteristics of pediatric meningiomas, including the clinical symptom, anatomic location, radiological finding, treatment approaches, and long-term surgical outcome as well as the possible influence factors of the prognosis.
We retrospectively reviewed the medical records and follow-up data of 39 pediatric patients who were treated by operation for intracranial meningiomas in West-China Hospital between 2009-2019.
The incidence of pediatric meningioma was 0.74%. The mean age at surgery was 12.2 years and the ratio of male to female was 1.3. Three cases (7.7%) were related to neurofibromas. WHO grade I was found in 26 patients (66.7%) and higher grades was seen in 13 (33.3%). The most common location sites were convexity (35.9%). Gross total excision was achieved in 28 patients (71.8%). The mean follow-up period was 54.4 months. The recurrence rate was 41.9%. By survival analysis, only gross total resection (p = 0.028) was associated with favorable outcome.
Meningiomas in children are very rare and have a slight male predominance. Pediatric meningiomas are more commonly located in intraventricular and have higher incidence rate of high-grade than that in adults. Although being challenging, the gross total excision should be underdone to achieve a better prognosis.
本文旨在研究儿童脑膜瘤的特点，包括临床症状、解剖部位、影像学表现、治疗方法和长期手术结果，以及可能影响预后的因素。
我们回顾性分析了 2009 年至 2019 年间在华西医院接受手术治疗的 39 例颅内脑膜瘤患儿的病历和随访资料。
儿童脑膜瘤的发病率为 0.74%。手术时的平均年龄为 12.2 岁，男女比例为 1.3。3 例（7.7%）与神经纤维瘤有关。26 例（66.7%）为 WHO Ⅰ级，13 例（33.3%）为高级别。最常见的部位是凸面（35.9%）。28 例（71.8%）达到大体全切除。平均随访时间为 54.4 个月。复发率为 41.9%。通过生存分析，只有大体全切除（p=0.028）与良好的预后相关。
儿童脑膜瘤非常罕见，略偏男性。儿童脑膜瘤更常见于脑室内，且高级别发病率高于成人。尽管具有挑战性，但应进行大体全切除以获得更好的预后。
