枯草芽孢杆菌作为活疫苗载体的应用：综述
Application of Bacillus subtilis as a live vaccine vector: A review.
作者信息
Lv Penghao, Song Yanying, Liu Cong, Yu Lanping, Shang Yingli, Tang Hui, Sun Shuhong, Wang Fangkun
机构信息
Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Shandong Agricultural University, Taian 271018, China.
Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Taian 271018, China.
出版信息
J Vet Med Sci. 2020 Dec 5;82(11):1693-1699. doi: 10.1292/jvms.20-0363. Epub 2020 Oct 16.
Abstract
Bacillus subtilis is widely used as a probiotic in various fields as it regulates intestinal flora, improves animal growth performance, enhances body immunity, has short fermentation cycle, and is economic. With the rapid development of DNA recombination technology, B. subtilis has been used as a potential vaccine expression vector for the treatment and prevention of various diseases caused by bacteria, viruses, and parasites as it can effectively trigger an immune response in the body. In this review, we refer to previous literature and provide a comprehensive analysis and overview of the feasibility of using B. subtilis as a vaccine expression vector, with an aim to provide a valuable reference for the establishment of efficient vaccines.
摘要
枯草芽孢杆菌作为一种益生菌在各个领域被广泛应用，因为它能调节肠道菌群、改善动物生长性能、增强机体免疫力，且发酵周期短、经济实惠。随着DNA重组技术的快速发展，枯草芽孢杆菌已被用作一种潜在的疫苗表达载体，用于治疗和预防由细菌、病毒及寄生虫引起的各种疾病，因为它能在体内有效触发免疫反应。在本综述中，我们参考了以往文献，对使用枯草芽孢杆菌作为疫苗表达载体的可行性进行了全面分析和概述，旨在为高效疫苗的研发提供有价值的参考。
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