Evaluation Potential Antidiabetic Effects of in Streptozotocin-Induced Diabetic Rats.

OBJECTIVES

The aim of the present work was to evaluate the possible beneficial effects of on blood glucose, lipids, and diabetes-related changes in the liver and kidney of streptozotocin-induced diabetic rats.

METHODS

Male Wistar rats were randomly allocated into four groups (n = 6) normal control rats, diabetic control rats, diabetic rats treated for 4 weeks with root (400 mg/kg/day), and diabetic rats treated with aerial parts (400 mg/kg/day).

RESULTS

Induction of diabetes significantly (p < 0.05) increased the levels of fasting blood glucose (FBG), triglyceride, total cholesterol, low-density lipoprotein (LDL), blood urea nitrogen (BUN), aspartate aminotransferase (AST), and alanine aminotransferase (ALT). Diabetes also increased (p < 0.05) oxidative stress in the kidney and liver (decrease of thiol and increase of superoxide dismutase). The root and aerial parts of significantly reduced the level of LDL (p < 0.05) and restored the content of thiol (p < 0.05) and superoxide dismutase (p < 0.01) in the kidney and liver. had no significant effect on the levels of FBG, BUN, AST, and ALT. The root of also reduced the serum level of total cholesterol (p < 0.05) and prevented the progression of hyperglycemia.

CONCLUSION

These findings suggest that may improve diabetic dyslipidemia by reducing serum LDL. Further studies are needed to confirm our findings.