Nagoshi C T, Wilson J R
Alcohol Clin Exp Res. 1987 Aug;11(4):392-8. doi: 10.1111/j.1530-0277.1987.tb01330.x.
As part of the Colorado Alcohol Research on Twins and Adoptees (CARTA), 35 subjects who reported having an alcoholic parent or sibling [family alcoholism history positive (FHP)] were matched with 35 controls [family alcoholism history negative (FHN)]. All subjects were tested three times on a battery of physiological, motor, and cognitive performance tasks before the ingestion of alcohol, then were tested three more times over a 3-hr period during which their blood alcohol concentration (BAC) was brought up to and maintained at about 0.10 g/dl by an initial large dose of ethanol and subsequent topping doses. FHP subjects scored significantly lower than FHN subjects on the Raven's Progressive Matrices and on some of the cognitive tasks before alcohol ingestion. FHP and FHN subjects, however, did not significantly differ in absorption and clearance of alcohol or in sensitivity and acute tolerance scores calculated on the repeated measures. Contrary to expectations, FHP subjects perceived themselves as being more impaired by alcohol than FHN subjects, and there was little evidence to suggest that they were less sensitive to variations in BAC.
作为科罗拉多双胞胎与领养者酒精研究（CARTA）的一部分，35名报告有酗酒父母或兄弟姐妹的受试者[家族酗酒史阳性（FHP）]与35名对照者[家族酗酒史阴性（FHN）]进行了匹配。所有受试者在饮酒前就一系列生理、运动和认知表现任务接受了三次测试，然后在3小时内又接受了三次测试，在此期间，通过初始大剂量乙醇和后续补充剂量，将他们的血液酒精浓度（BAC）提高并维持在约0.10 g/dl。在饮酒前，FHP受试者在瑞文渐进性矩阵测验和一些认知任务上的得分显著低于FHN受试者。然而，FHP和FHN受试者在酒精吸收和清除方面，或在基于重复测量计算的敏感性和急性耐受性得分方面，并无显著差异。与预期相反，FHP受试者认为自己比FHN受试者受酒精影响更大，而且几乎没有证据表明他们对BAC的变化不太敏感。
