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自制具有纳米气溶胶过滤效率的口罩用于社区缓解 COVID-19 大流行。

Home-made masks with filtration efficiency for nano-aerosols for community mitigation of COVID-19 pandemic.

机构信息

HKU-Pasteur Research Pole, School of Public Health, The University of Hong Kong, Sassoon Road, Pokfulam, Hong Kong, China.

Department of Surgery, The University of Hong Kong-Shenzhen Hospital, Futian District, Shenzhen, China; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Sassoon Road, Pokfulam, Hong Kong, China.

出版信息

Public Health. 2020 Nov;188:42-50. doi: 10.1016/j.puhe.2020.08.018. Epub 2020 Sep 2.

Abstract

OBJECTIVES

The novel coronavirus disease 2019 (COVID-19) epidemic that emerged in December 2019 has rapidly evolved in recent months to become a worldwide and ongoing pandemic. Shortage of medical masks remains an unresolved problem. This study aims to investigate the filtration efficiency (FE) of home-made masks that could be used as alternatives for community mitigation of COVID-19.

STUDY DESIGN

Experimental observational analytic study.

METHODS

The FE of home-made masks and medical masks (as the control) were tested under laminar flow within a scaled air duct system using nebulised NaCl aerosols sized 6-220 nm. The size-resolved NaCl aerosol count was measured using a scanning mobility particle-sizer spectrometer. Home-made masks with an external plastic face shield also underwent a splash test. In addition, the fibre structures of medical masks were studied under an electron microscope after treatment with either 75% alcohol or soap and water at 60 °C.

RESULTS

The FE of the home-made masks at 6-200 nm were non-inferior to that of medical masks (84.54% vs 86.94%, P = 0.102). Both types of masks achieved an FE of 90% at 6-89 nm. A significantly higher FE was achieved when one piece of tissue paper was added adjacent to the inner surface of the medical mask than medical mask alone (6-200 nm: 91.64% vs 86.94%, P < 0.0001; 6-89 nm: 94.27% vs 90.54%, P < 0.0001; 90-200 nm: 82.69% vs 73.81%, P < 0.0001). The plastic face shield prevented the home-made mask from fluid splash. The fibre structures of the external surface of medical masks were damaged after treatment with either 75% alcohol or soap and water at 60 °C.

CONCLUSIONS

The home-made masks in this study, which were made of one piece of tissue paper and two pieces of kitchen towels, layered from face to external, had an FE at 6-200 nm non-inferior to that of medical mask materials, which had a certified FE of ≥95% at 3 μm. In the current COVID-19 pandemic with the shortage of medical masks, these home-made masks combined with an external plastic shield could be used as an alternative to medical masks for community mitigation. In addition, one piece of tissue paper could be placed adjacent to the inner surface of a medical mask to prolong effective lifespan of the medical mask. These demand reduction strategies could be used to reserve medical masks for use in healthcare and certain high-risk community settings, such as symptomatic persons, caregivers and attendees to healthcare institutions.

摘要

目的

2019 年 12 月出现的新型冠状病毒病(COVID-19)疫情在近几个月迅速演变成为全球持续流行的大流行病。医用口罩短缺仍然是一个未解决的问题。本研究旨在研究自制口罩的过滤效率(FE),这些口罩可作为社区缓解 COVID-19 的替代品。

设计

实验性观察分析研究。

方法

使用喷雾化的 NaCl 气溶胶(大小为 6-220nm)在缩放空气管道系统内对自制口罩和医用口罩(作为对照)的 FE 进行了测试。使用扫描迁移率颗粒谱仪测量了大小分辨的 NaCl 气溶胶计数。带有外部塑料面罩的自制口罩还进行了飞溅测试。此外,在用 75%酒精或在 60°C 下用肥皂和水对医用口罩的纤维结构进行处理后,在电子显微镜下研究了医用口罩的纤维结构。

结果

在 6-200nm 时,自制口罩的 FE 不低于医用口罩(84.54%对 86.94%,P=0.102)。两种类型的口罩在 6-89nm 时均达到 90%的 FE。当在医用口罩的内表面附近添加一张纸巾时,口罩的 FE 显著提高(6-200nm:91.64%对 86.94%,P<0.0001;6-89nm:94.27%对 90.54%,P<0.0001;90-200nm:82.69%对 73.81%,P<0.0001)。塑料面罩可防止自制口罩受到液体飞溅的影响。在用 75%酒精或在 60°C 下用肥皂和水对医用口罩的外部表面进行处理后,其纤维结构受到破坏。

结论

本研究中使用的自制口罩由一张纸巾和两张厨房毛巾组成,从面部到外部分层,其在 6-200nm 时的 FE 不低于医用口罩材料的 FE,后者在 3μm 时具有认证的≥95%的 FE。在当前 COVID-19 大流行期间,医用口罩短缺,这些带有外部塑料罩的自制口罩可替代医用口罩用于社区缓解。此外,可以在医用口罩的内表面附近放置一张纸巾,以延长医用口罩的有效使用寿命。这些减少需求的策略可用于将医用口罩保留给医疗保健和某些高风险社区环境(例如有症状者,护理人员和医疗机构的访客)使用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ace/7466940/4528db258f28/gr1_lrg.jpg

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