Institute of Life Course and Medical Sciences, University of Liverpool, Brownlow Hill, Liverpool L69 3BX, UK.
Department of Rheumatology, Aintree Hospital, Liverpool University Hospitals NHS Foundation Trust, Lower Lane L9 7AL, UK.
Nutrients. 2020 Oct 15;12(10):3155. doi: 10.3390/nu12103155.
The role of nutrition in the pathogenesis of rheumatic diseases, including rheumatoid arthritis (RA), has gained increasing attention in recent years. A growing number of studies have focussed on the diverse nutritional contents of beverages, and their possible role in the development and progression of RA. Main body: We aimed to summarise the current knowledge on the role of a range of beverages in the context of RA. Beverages have a key role within the mosaic of autoimmunity in RA and potential to alter the microbiome, leading to downstream effects on inflammatory pathways. The molecular contents of beverages, including coffee, tea, and wine, have similarly been found to interfere with immune signalling pathways, some beneficial for disease progression and others less so. Finally, we consider beverages in the context of wider dietary patterns, and how this growing body of evidence may be harnessed by the multidisciplinary team in patient management.
While there is increasing work focussing on the role of beverages in RA, integration of discussions around diet and lifestyle in our management of patients remains sparse. Nutrition in RA remains a controversial topic, but future studies, especially on the role of beverages, are likely to shed further light on this in coming years.
近年来，营养在风湿性疾病（包括类风湿关节炎）发病机制中的作用引起了越来越多的关注。越来越多的研究集中在饮料的各种营养成分上，以及它们在类风湿关节炎的发展和进展中的可能作用。
我们旨在总结目前关于各种饮料在类风湿关节炎背景下作用的知识。饮料在类风湿关节炎的自身免疫马赛克中起着关键作用，并有可能改变微生物组，从而对炎症途径产生下游影响。饮料的分子成分，包括咖啡、茶和葡萄酒，同样被发现干扰免疫信号通路，有些对疾病进展有益，有些则不然。最后，我们考虑了在更广泛的饮食模式背景下的饮料，以及多学科团队在患者管理中如何利用这一不断增长的证据。
虽然越来越多的工作集中在饮料在类风湿关节炎中的作用上，但在我们对患者的管理中，围绕饮食和生活方式的讨论仍然很少。类风湿关节炎的营养仍然是一个有争议的话题，但未来的研究，特别是关于饮料的作用，很可能在未来几年进一步阐明这一点。
