Yan Xuehui, Huang Shujing, Wang Yong, Tang Yuanyuan, Tian Ye
College of Engineering and Applied Sciences, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing 210023, China.
Shenzhen Research Institute of Nanjing University, Shenzhen 518000, China.
Nanomaterials (Basel). 2020 Oct 16;10(10):2047. doi: 10.3390/nano10102047.
Manipulating materials at the atomic scale is one of the goals of the development of chemistry and materials science, as it provides the possibility to customize material properties; however, it still remains a huge challenge. Using DNA self-assembly, materials can be controlled at the nano scale to achieve atomic- or nano-scaled fabrication. The programmability and addressability of DNA molecules can be applied to realize the self-assembly of materials from the bottom-up, which is called DNA nanotechnology. DNA nanotechnology does not focus on the biological functions of DNA molecules, but combines them into motifs, and then assembles these motifs to form ordered two-dimensional (2D) or three-dimensional (3D) lattices. These lattices can serve as general templates to regulate the assembly of guest materials. In this review, we introduce three typical DNA self-assembly strategies in this field and highlight the significant progress of each. We also review the application of DNA self-assembly and propose perspectives in this field.
在原子尺度上操纵材料是化学和材料科学发展的目标之一，因为它提供了定制材料特性的可能性；然而，这仍然是一个巨大的挑战。利用DNA自组装，可以在纳米尺度上控制材料，以实现原子级或纳米级制造。DNA分子的可编程性和可寻址性可用于实现材料的自下而上自组装，这被称为DNA纳米技术。DNA纳米技术并不关注DNA分子的生物学功能，而是将它们组合成基序，然后组装这些基序以形成有序的二维（2D）或三维（3D）晶格。这些晶格可以作为通用模板来调节客体材料的组装。在本综述中，我们介绍了该领域三种典型的DNA自组装策略，并强调了每种策略的重大进展。我们还回顾了DNA自组装的应用，并提出了该领域的展望。
