Department of Chemistry, New York University, New York 10003, USA.
Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.
Nat Chem. 2017 Aug;9(8):824-827. doi: 10.1038/nchem.2745. Epub 2017 Mar 14.
Structural DNA nanotechnology finds applications in numerous areas, but the construction of objects, 2D and 3D crystalline lattices and devices is prominent among them. Each of these components has been developed individually, and most of them have been combined in pairs. However, to date there are no reports of independent devices contained within 3D crystals. Here we report a three-state 3D device whereby we change the colour of the crystals by diffusing strands that contain dyes in or out of the crystals through the mother-liquor component of the system. Each colouring strand is designed to pair with an extended triangle strand by Watson-Crick base pairing. The arm that contains the dyes is quite flexible, but it is possible to establish the presence of the duplex proximal to the triangle by X-ray crystallography. We modelled the transition between the red and blue states through a simple kinetic model.
结构 DNA 纳米技术在许多领域都有应用，但其中突出的是构建物体、2D 和 3D 晶体格子和器件。这些组件中的每一个都已经被单独开发，其中大多数已经被成对地组合在一起。然而，迄今为止，还没有报道在 3D 晶体中包含独立的器件。在这里，我们报告了一个三态 3D 器件，通过扩散包含染料的链，我们可以通过系统的母液成分将染料在晶体内外扩散，从而改变晶体的颜色。每个染色链都设计成通过 Watson-Crick 碱基配对与扩展的三角形链配对。含有染料的臂非常灵活，但通过 X 射线晶体学可以确定在三角形附近存在双链体。我们通过一个简单的动力学模型来模拟红色和蓝色状态之间的转变。
