老年结直肠癌患者预后列线图的建立：一项监测、流行病学和最终结果（SEER）数据库分析
Establishment of prognostic nomogram for elderly colorectal cancer patients: a SEER database analysis.
作者信息
Yu Chaoran, Zhang Yujie
机构信息
Fudan University Shanghai Cancer Center, Fudan University, Dongan Road 270, Shanghai, 200025, P. R. China.
Department of Oncology, Shanghai Medical College, Fudan University, Dongan Road 270, Shanghai, 200025, P. R. China.
出版信息
BMC Gastroenterol. 2020 Oct 20;20(1):347. doi: 10.1186/s12876-020-01464-z.
BACKGROUND
This study aimed to establish nomogram models of overall survival (OS) and cancer-specific survival (CSS) in elderly colorectal cancer (ECRC) patients (Age ≥ 70).
METHODS
The clinical variables of patients confirmed as ECRC between 2004 and 2016 were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate analysis were performed, followed by the construction of nomograms in OS and CSS.
RESULTS
A total of 44,761 cases were finally included in this study. Both C-index and calibration plots indicated noticeable performance of newly established nomograms. Moreover, nomograms also showed higher outcomes of decision curve analysis (DCA) and the area under the curve (AUC) compared to American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM) stage and SEER stage.
CONCLUSIONS
This study established nomograms of elderly colorectal cancer patients with distinct clinical values compared to AJCC TNM and SEER stages regarding both OS and CSS.
背景
本研究旨在建立老年结直肠癌（ECRC）患者（年龄≥70岁）的总生存（OS）和癌症特异性生存（CSS）列线图模型。
方法
从监测、流行病学和最终结果（SEER）数据库中检索2004年至2016年确诊为ECRC患者的临床变量。进行单因素和多因素分析，随后构建OS和CSS的列线图。
结果
本研究最终共纳入44,761例病例。C指数和校准图均表明新建立的列线图具有显著性能。此外，与美国癌症联合委员会（AJCC）肿瘤-淋巴结-转移（TNM）分期和SEER分期相比，列线图在决策曲线分析（DCA）和曲线下面积（AUC）方面也显示出更高的结果。
结论
本研究建立了老年结直肠癌患者的列线图，在OS和CSS方面与AJCC TNM和SEER分期相比具有独特的临床价值。
Zotero 插件