文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

基于海藻酸盐的癌症靶向药物递送平台。

Alginate-Based Platforms for Cancer-Targeted Drug Delivery.

机构信息

College of Pharmacy, Southwest Minzu University, Chengdu 610041, China.

Department of Orthopedics, The People's Hospital of China Three Gorges University, First People's Hospital of Yichang, Yichang 443000, China.

出版信息

Biomed Res Int. 2020 Oct 7;2020:1487259. doi: 10.1155/2020/1487259. eCollection 2020.

DOI:10.1155/2020/1487259
PMID:33083451
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7563048/
Abstract

As an acidic, ocean colloid polysaccharide, alginate is both a biopolymer and a polyelectrolyte that is considered to be biocompatible, nontoxic, nonimmunogenic, and biodegradable. A significant number of studies have confirmed the potential use of alginate-based platforms as effective vehicles for drug delivery for cancer-targeted treatment. In this review, the focus is on the formation of alginate-based cancer-targeted delivery systems. Specifically, some general chemical and physical properties of alginate and different types of alginate-based delivery systems are discussed, and various kinds of alginate-based carriers are introduced. Finally, recent innovative strategies to functionalize alginate-based vehicles for cancer targeting are described to highlight research towards the optimization of alginate.

摘要

藻酸盐是一种酸性海洋胶体多糖，既是生物聚合物又是聚电解质，被认为是生物相容、无毒、无免疫原性和可生物降解的。大量研究证实，基于藻酸盐的平台可作为用于癌症靶向治疗的有效药物递送载体。在这篇综述中，重点关注基于藻酸盐的癌症靶向递药系统的形成。具体而言，讨论了藻酸盐的一些一般化学和物理性质以及不同类型的基于藻酸盐的递药系统，并介绍了各种基于藻酸盐的载体。最后，描述了用于癌症靶向的基于藻酸盐的载体的功能化的一些创新性策略，以突出对藻酸盐的优化研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7d8/7563048/37a43339b987/BMRI2020-1487259.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7d8/7563048/4eb9e3713824/BMRI2020-1487259.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7d8/7563048/694fd264a554/BMRI2020-1487259.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7d8/7563048/e587b2fb3c04/BMRI2020-1487259.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7d8/7563048/5c49556e5d87/BMRI2020-1487259.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7d8/7563048/c2641e23bc01/BMRI2020-1487259.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7d8/7563048/37a43339b987/BMRI2020-1487259.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7d8/7563048/4eb9e3713824/BMRI2020-1487259.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7d8/7563048/694fd264a554/BMRI2020-1487259.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7d8/7563048/e587b2fb3c04/BMRI2020-1487259.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7d8/7563048/5c49556e5d87/BMRI2020-1487259.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7d8/7563048/c2641e23bc01/BMRI2020-1487259.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7d8/7563048/37a43339b987/BMRI2020-1487259.006.jpg

相似文献

[1]
Alginate-Based Platforms for Cancer-Targeted Drug Delivery.

Biomed Res Int. 2020

[2]
Biopolymeric alginate-chitosan nanoparticles as drug delivery carriers for cancer therapy.

Pharmazie. 2014-8

[3]
On-Chip Preparation of Amphiphilic Nanomicelles-in-Sodium Alginate Spheroids as a Novel Platform Against Triple-Negative Human Breast Cancer Cells: Fabrication, Study of Microfluidics Flow Hydrodynamics and Proof of Concept for Anticancer and Drug Delivery Applications.

J Pharm Sci. 2019-7-25

[4]
Alginate Based Nanocarriers for Drug Delivery Applications.

Curr Pharm Des. 2016

[5]
Alginate drug delivery systems: application in context of pharmaceutical and biomedical research.

Drug Dev Ind Pharm. 2014-12

[6]
A comprehensive review on alginate-based delivery systems for the delivery of chemotherapeutic agent: Doxorubicin.

Carbohydr Polym. 2021-5-1

[7]
Smart Stimuli-responsive Alginate Nanogels for Drug Delivery Systems and Cancer Therapy: A Review.

Curr Pharm Des. 2023

[8]
Designing colon-specific delivery systems for anticancer drug-loaded nanoparticles: an evaluation of alginate carriers.

J Biomed Mater Res A. 2014-9

[9]
Alginate-based hydrogels for cancer therapy and research.

Int J Biol Macromol. 2021-2-15

[10]
Alginate Nanoparticles for Drug Delivery and Targeting.

Curr Pharm Des. 2019

引用本文的文献

[1]
Natural carrier systems in cancer vaccines and immunotherapy.

Hum Vaccin Immunother. 2025-12

[2]
Microfluidic Production of Spatially Structured Biomimetic Microgels as Compartmentalized Artificial Cells.

Small Sci. 2025-2-6

[3]
Exploring New Frontiers: Alternative Breast Cancer Treatments Through Glycocalyx Research.

Breast J. 2025-5-22

[4]
Flavonoid-Based Nanogels: A Comprehensive Overview.

Gels. 2025-4-4

[5]
Beyond Needles: Immunomodulatory Hydrogel-Guided Vaccine Delivery Systems.

Gels. 2024-12-26

[6]
The selective proapoptotic impact of the myricetin-loaded alginate-cellulose hybrid nanocrystals (MAC-NCs) on the human AGS gastric cancer cells.

Mol Biol Rep. 2024-9-19

[7]
Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications.

Beilstein J Nanotechnol. 2024-8-22

[8]
Oral co-polymeric raft-forming nano gels for targeted empagliflozin delivery against stomach cancer (SGC7901).

Heliyon. 2024-7-4

[9]
Glycan-based scaffolds and nanoparticles as drug delivery system in cancer therapy.

Front Immunol. 2024

[10]
Alginate Nanoparticles Containing and Essential Oils with Promising Anticancer and Antibacterial Effects.

Int J Biomater. 2024-5-2

本文引用的文献

[1]
pH-Sensitive Folic Acid Conjugated Alginate Nanoparticle for Induction of Cancer-Specific Fluorescence Imaging.

Pharmaceutics. 2020-6-11

[2]
Inverse-micelle synthesis of doxorubicin-loaded alginate/chitosan nanoparticles and assessment of breast cancer cytotoxicity.

Colloid Interface Sci Commun. 2019-1

[3]
Nanogels Derived from Fish Gelatin: Application to Drug Delivery System.

Mar Drugs. 2019-4-25

[4]
Interpenetration of Natural Polymer Aerogels by Supercritical Drying.

Polymers (Basel). 2016-3-24

[5]
Fabrication and characterization of hydroxyapatite/sodium alginate/chitosan composite microspheres for drug delivery and bone tissue engineering.

Mater Sci Eng C Mater Biol Appl. 2019-3-11

[6]
Physical stimuli-responsive vesicles in drug delivery: Beyond liposomes and polymersomes.

Adv Drug Deliv Rev. 2018-10-25

[7]
Dual-layered pH-sensitive alginate/chitosan/kappa-carrageenan microbeads for colon-targeted release of 5-fluorouracil.

Int J Biol Macromol. 2019-3-30

[8]
Enhancement of chemoradiation by co-incorporation of gold nanoparticles and cisplatin into alginate hydrogel.

J Biomed Mater Res B Appl Biomater. 2019-3-13

[9]
Recent Progress of Polymeric Nanogels for Gene Delivery.

Curr Opin Colloid Interface Sci. 2019-2

[10]
Natural biodegradable polymers based nano-formulations for drug delivery: A review.

Int J Pharm. 2019-3-6

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索