基于海藻酸盐的癌症靶向药物递送平台。

College of Pharmacy, Southwest Minzu University, Chengdu 610041, China.

Department of Orthopedics, The People's Hospital of China Three Gorges University, First People's Hospital of Yichang, Yichang 443000, China.

Biomed Res Int. 2020 Oct 7;2020:1487259. doi: 10.1155/2020/1487259. eCollection 2020.

As an acidic, ocean colloid polysaccharide, alginate is both a biopolymer and a polyelectrolyte that is considered to be biocompatible, nontoxic, nonimmunogenic, and biodegradable. A significant number of studies have confirmed the potential use of alginate-based platforms as effective vehicles for drug delivery for cancer-targeted treatment. In this review, the focus is on the formation of alginate-based cancer-targeted delivery systems. Specifically, some general chemical and physical properties of alginate and different types of alginate-based delivery systems are discussed, and various kinds of alginate-based carriers are introduced. Finally, recent innovative strategies to functionalize alginate-based vehicles for cancer targeting are described to highlight research towards the optimization of alginate.

藻酸盐是一种酸性海洋胶体多糖，既是生物聚合物又是聚电解质，被认为是生物相容、无毒、无免疫原性和可生物降解的。大量研究证实，基于藻酸盐的平台可作为用于癌症靶向治疗的有效药物递送载体。在这篇综述中，重点关注基于藻酸盐的癌症靶向递药系统的形成。具体而言，讨论了藻酸盐的一些一般化学和物理性质以及不同类型的基于藻酸盐的递药系统，并介绍了各种基于藻酸盐的载体。最后，描述了用于癌症靶向的基于藻酸盐的载体的功能化的一些创新性策略，以突出对藻酸盐的优化研究。