Kandil Rima, Merkel Olivia M
Department of Pharmacy, Pharmaceutical Technology and Biopharmacy, Ludwig-Maximilians-University, Butenandtstraße 5-13, 81337, Munich, Germany.
Curr Opin Colloid Interface Sci. 2019 Feb;39:11-23. doi: 10.1016/j.cocis.2019.01.005. Epub 2019 Jan 16.
With its nearly unrestricted possibilities, gene therapy attracts more and more significance in modern-day research. The only issue still seeming to hold back its clinical success is the actual effective delivery of genetic material. Nucleic acids are in general challenging to administer to their intracellular targets due to their unfavorable pharmaceutical characteristics. Polymeric nanogels present a promising delivery platform for oligonucleotide-based therapies, as the growing number of reports deliberated in this review represents. Within the scope of this article, recent progress in the employment of nanogels as gene delivery vectors is summarized and different examples of modified, stimuli-responsive, targeted and co-delivering nanogels are discussed in detail. Furthermore, major aspects of successful gene delivery are addressed and critically debated in regards to nanogels, giving insights into what progress has been made and which key issues still need to be further approached.
基因治疗具有几乎不受限制的可能性，在现代研究中越来越受到重视。目前唯一似乎阻碍其临床成功的问题是遗传物质的实际有效递送。由于核酸不利的药物特性，将其递送至细胞内靶点通常具有挑战性。正如本综述中越来越多的报道所表明的那样，聚合物纳米凝胶为基于寡核苷酸的治疗提供了一个有前景的递送平台。在本文范围内，总结了纳米凝胶作为基因递送载体应用的最新进展，并详细讨论了修饰的、刺激响应型、靶向型和共递送纳米凝胶的不同实例。此外，还讨论了成功进行基因递送的主要方面，并对纳米凝胶进行了批判性辩论，以深入了解已取得的进展以及仍需进一步解决的关键问题。
