Subramanian Indu, Farahnik Joshua, Mischley Laurie K
David Geffen School of Medicine, UCLA, Department of Neurology, Los Angeles, CA USA.
PADRECC, West Los Angeles, Veterans Administration, Los Angeles, CA USA.
NPJ Parkinsons Dis. 2020 Oct 8;6:28. doi: 10.1038/s41531-020-00128-9. eCollection 2020.
Social isolation and its deleterious effects on health increases with age in the general population. People with Parkinson's Disease (PWP) are no exception. Social isolation is a risk factor for worsened health outcomes and increased mortality. Symptoms such as depression and sleep dysfunction are adversely affected by loneliness. There is a paucity of research on social isolation in Parkinson's disease (PD), which is all the more critical now in the setting of social distancing due to COVID-19. The goal of this study was to survey individuals with PD to evaluate whether social isolation is associated with PD symptom severity and quality of life. Only individuals reporting a diagnosis of idiopathic PD were included in this analysis. The primary outcome measures were the Patient-Reported Outcomes in PD (PRO-PD) and questions from PROMIS Global related to social health. PRO-PD scores increased as social performance and social satisfaction scores diminished. Individuals who reported being lonely experienced a 55% greater symptom severity than those who were not lonely ( < 0.01). Individuals who documented having a lot of friends had 21% fewer symptoms than those with few or no friends ( < 0.01). Social isolation was associated with greater patient-reported PD severity and lower quality of life, although it is unclear whether this is the cause and/or a consequence of the disease. In essence, the Parkinson pandemic and the pandemic of social isolation have been further compounded by the recent COVID-19 pandemic. The results emphasize the need to keep PWP socially connected and prevent loneliness in this time of social distancing. Proactive use of virtual modalities for support groups and social prescribing should be explored.
在普通人群中，社会隔离及其对健康的有害影响会随着年龄的增长而增加。帕金森病患者（PWP）也不例外。社会隔离是健康状况恶化和死亡率增加的一个风险因素。抑郁和睡眠功能障碍等症状会受到孤独的不利影响。关于帕金森病（PD）中社会隔离的研究很少，在因新冠疫情而保持社交距离的背景下，这一点现在显得尤为关键。本研究的目的是对帕金森病患者进行调查，以评估社会隔离是否与帕金森病症状严重程度和生活质量相关。本分析仅纳入报告患有特发性帕金森病的个体。主要结局指标是帕金森病患者报告结局量表（PRO-PD）以及来自PROMIS Global与社会健康相关的问题。随着社交表现和社交满意度得分的降低，PRO-PD得分升高。报告感到孤独的个体的症状严重程度比不孤独的个体高55%（<0.01）。记录显示有很多朋友的个体的症状比朋友很少或没有朋友的个体少21%（<0.01）。社会隔离与患者报告的更高的帕金森病严重程度和更低的生活质量相关，尽管尚不清楚这是疾病的原因还是结果。从本质上讲，帕金森病大流行和社会隔离大流行因最近的新冠疫情而进一步加剧。结果强调了在社交距离时期保持帕金森病患者社交联系并防止孤独的必要性。应探索积极利用虚拟模式开展支持小组和社会处方。
