Tabrizi Shamsoreza Tabriznia, Gholampour Marzieh, Zarmehri Azam Moradi, Sadeghian Mohammad Hadi, Keramati Mohammad Reza
Hematology Lab, Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Niger Med J. 2020 May-Jun;61(3):151-155. doi: 10.4103/nmj.NMJ_127_19. Epub 2020 Jul 4.
Human T-cell lymphotropic virus (HTLV-I) is the causative agent for adult T-cell lymphoma/leukemia (ATLL) and HTLV-I-associated myelopathy/tropical spastic paraparesis. The virus is endemic in the parts of Iran. This study is conducted to determine the trends in the frequency of HTLV-I in Mashhad, a city in Khorasan-e Razavi province, Iran, over 11 years.
Blood bank records of blood donors positive for HTLV-I were collected from different blood banks across Mashhad between 2002 and 2013. Obtained data were first entered into paper versions and then were analyzed by SPSS version 11.5. HTLV-I antibody was firstly measured by enzyme-linked immunosorbent assay (ELISA) method and later confirmed by the Western Blot (WB).
During the study period, 983,000 donors were examined by ELISA and WB, among whom 2921 cases (0.297%) were positive HTLV-I carriers. The highest and lowest frequency of carriers was 0.451% and 0.098%, respectively. The most significant factor was related to marital status (85.2%) and the smallest significant factor was associated with the history of acupuncture (0.3%) according to the different risk factors.
The frequency of HTLV-I carriers among blood donors was significantly decreased in this period. Screening of blood donors for HTLV-I infection played a significant role in this reduction.
人类嗜T细胞病毒1型（HTLV-I）是成人T细胞淋巴瘤/白血病（ATLL）和HTLV-I相关脊髓病/热带痉挛性截瘫的病原体。该病毒在伊朗部分地区呈地方性流行。本研究旨在确定伊朗霍拉桑-拉扎维省马什哈德市11年间HTLV-I感染率的变化趋势。
收集2002年至2013年间马什哈德市不同血库中HTLV-I检测呈阳性的献血者的血库记录。获取的数据首先录入纸质版本，然后用SPSS 11.5版进行分析。HTLV-I抗体首先通过酶联免疫吸附测定（ELISA）法检测，随后通过免疫印迹法（WB）进行确认。
在研究期间，通过ELISA和WB检测了983,000名献血者，其中2921例（0.297%）为HTLV-I阳性携带者。携带者的最高和最低感染率分别为0.451%和0.098%。根据不同的风险因素，最显著的因素与婚姻状况有关（85.2%），最不显著的因素与针灸史有关（0.3%）。
在此期间，献血者中HTLV-I携带者的感染率显著下降。对献血者进行HTLV-I感染筛查在这一下降过程中发挥了重要作用。
