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Hemostatic Abnormality and Associated Factors in Diabetic Patients at Jimma University Specialized Hospital, Jimma, Southwest Ethiopia: A Comparative Cross-sectional Study.埃塞俄比亚西南部吉马市吉马大学专科医院糖尿病患者的止血异常及相关因素：一项比较性横断面研究
Ethiop J Health Sci. 2019 Mar;29(2):251-258. doi: 10.4314/ejhs.v29i2.12.
2
Shortened Activated Partial Thromboplastin Time and Increased Superoxide Dismutase Levels Are Associated with Type 2 Diabetes Mellitus.活化部分凝血活酶时间缩短和超氧化物歧化酶水平升高与2型糖尿病有关。
Ann Clin Lab Sci. 2018 Jul;48(4):469-477.
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Plasminogen Activator Inhibitor-1 Level Correlates with Lipoprotein Subfractions in Obese Nondiabetic Subjects.纤溶酶原激活物抑制剂-1水平与肥胖非糖尿病受试者的脂蛋白亚组分相关。
Int J Endocrinol. 2018 May 30;2018:9596054. doi: 10.1155/2018/9596054. eCollection 2018.
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Plasma Fibrinogen in Type 2 Diabetic Patients with Metabolic Syndrome and its Relation with Ischemic Heart Disease (IHD) and Retinopathy.2型糖尿病合并代谢综合征患者的血浆纤维蛋白原及其与缺血性心脏病（IHD）和视网膜病变的关系。
J Clin Diagn Res. 2015 Jan;9(1):BC18-21. doi: 10.7860/JCDR/2015/10712.5449. Epub 2015 Jan 1.
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Association of activated partial thromboplastin time and fibrinogen level in patients with type II diabetes mellitus.2型糖尿病患者活化部分凝血活酶时间与纤维蛋白原水平的相关性
BMC Res Notes. 2013 Nov 25;6:485. doi: 10.1186/1756-0500-6-485.
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Adipokines (adiponectin and plasminogen activator inhhibitor-1) in metabolic syndrome.代谢综合征中的脂肪因子（脂联素和纤溶酶原激活物抑制剂-1）
Indian J Endocrinol Metab. 2012 Jan;16(1):116-23. doi: 10.4103/2230-8210.91206.
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Diabetes mellitus is associated with shortened activated partial thromboplastin time and increased fibrinogen values.糖尿病与活化部分凝血活酶时间缩短和纤维蛋白原值升高有关。
PLoS One. 2011 Jan 28;6(1):e16470. doi: 10.1371/journal.pone.0016470.
8
Inverse relationship between adiponectin and plasminogen activator inhibitor-1 in metabolic syndrome patients.代谢综合征患者中脂联素与纤溶酶原激活物抑制剂-1之间的负相关关系。
Endocr Regul. 2008 Jun;42(2-3):63-8.
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Metabolic syndrome--a new world-wide definition. A Consensus Statement from the International Diabetes Federation.代谢综合征——一个新的全球定义。国际糖尿病联盟的共识声明。
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Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition.代谢综合征的定义：美国国立心肺血液研究所/美国心脏协会关于定义相关科学问题会议的报告。
Circulation. 2004 Jan 27;109(3):433-8. doi: 10.1161/01.CIR.0000111245.75752.C6.

代谢综合征中血栓前状态变化的研究。

Study of Prothrombotic Changes in Metabolic Syndrome.

作者信息

Khunger Jitender Mohan, Kumar Nitin, Punia V P S, Malhotra Monica Khunger

机构信息

Haematology Deptt, Vardhman Mahavir Medical College and Safdar Jang Hospital, New Delhi, 110029 India.

Medicine Department, Vardhman Mahavir Medical College and Safdar Jang Hospital, New Delhi, 110029 India.

出版信息

Indian J Hematol Blood Transfus. 2020 Oct;36(4):695-699. doi: 10.1007/s12288-020-01291-y. Epub 2020 May 20.

DOI:10.1007/s12288-020-01291-y
PMID:33100712
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7572991/
Abstract

The metabolic syndrome is a complex disorder of various metabolic risk factors in a single individual having central obesity and commonly associated with diabetes and cardiovascular diseases. The aim of our study was to study the relationship between coagulation abnormalities and metabolic syndrome. We performed a prospective cross-sectional study in a tertiary care hospital. A total of fifty cases of metabolic syndrome and fifty age & sex matched controls were selected. These two groups were investigated for Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT), Fibrinogen levels, Plasminogen Activator Inhibitor 1(PAI1) levels and Factor VIII levels. In cases with metabolic syndrome, significantly increased levels of Fibrinogen, Factor VIII and Plasminogen Activator Inhibitor1 (PAI1) were observed. PT & APTT were shorter in cases with metabolic syndrome. The coagulation parameters studied, correlated significantly with the components of metabolic syndrome. Metabolic syndrome is a hypercoagulable state and further studies are required for further evaluation of the consequences of this hypercoagulable state. There is a need for clinical trials evaluating prophylactic anticoagulation for prevention of venous thrombosis in patients with metabolic syndrome.

摘要

代谢综合征是一种复杂的疾病，在同一个体中存在多种代谢风险因素，伴有中心性肥胖，且通常与糖尿病和心血管疾病相关。我们研究的目的是探讨凝血异常与代谢综合征之间的关系。我们在一家三级医疗中心进行了一项前瞻性横断面研究。共选取了50例代谢综合征患者和50例年龄及性别匹配的对照。对这两组人群进行了凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、纤维蛋白原水平、纤溶酶原激活物抑制剂1（PAI1）水平及因子VIII水平的检测。在代谢综合征患者中，观察到纤维蛋白原、因子VIII及纤溶酶原激活物抑制剂1（PAI1）水平显著升高。代谢综合征患者的PT和APTT较短。所研究的凝血参数与代谢综合征的各组分显著相关。代谢综合征是一种高凝状态，需要进一步研究以进一步评估这种高凝状态的后果。有必要进行临床试验，评估预防性抗凝治疗对代谢综合征患者预防静脉血栓形成的作用。