Zhu Ruyi, Xu Xiaofen, Ying Jialiang, Cao Gang, Wu Xin
College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Front Pharmacol. 2020 Sep 25;11:550497. doi: 10.3389/fphar.2020.550497. eCollection 2020.
Diels & Gilg (TDG), the family member of Vitaceae, is a traditional herbal medicine in China. The root of TDG can be immediately used after cleaning the muddy soil, and can be dehydrated for dry use. TDG is able to be collected all year round, which is commonly used in the treatment of hepatitis, infantile high fever, snake bite, etc. Based on phytochemistry, the chemical components of TDG are divided into flavonoids, phenolic acids, terpenes, steroids, polysaccharide, and other compounds, showing many pharmacological effects which include anti-tumor, anti-oxidation, anti-inflammatory, antipyretic, analgesic, and immunomodulatory activity, as well as other activities. Currently, TDG involves some problems of the reduction of wild resources, the backward processing methods, and storage difficulties as well as the imperfection of detection methods. Therefore, this review summarizes the literature of the past 20 years, and the purpose of this review is to summarize the recent researches on the phytochemistry, pharmacology, quality control, and clinical application of TDG. The above discussions provide new insights for the future research on TDG.
蛇葡萄属（Diels & Gilg，TDG）是葡萄科的一个属，是中国的一种传统草药。蛇葡萄的根在洗净泥土后可直接使用，也可脱水干燥后使用。蛇葡萄全年均可采收，常用于治疗肝炎、小儿高热、蛇咬伤等。从植物化学角度来看，蛇葡萄的化学成分分为黄酮类、酚酸类、萜类、甾体类、多糖类等化合物，具有多种药理作用，包括抗肿瘤、抗氧化、抗炎、解热、镇痛、免疫调节活性等以及其他活性。目前，蛇葡萄存在野生资源减少、加工方法落后、储存困难以及检测方法不完善等问题。因此，本综述总结了过去20年的文献，目的是总结蛇葡萄在植物化学、药理学、质量控制和临床应用方面的最新研究。上述讨论为蛇葡萄未来的研究提供了新的见解。
