Cardiovascular Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Ann Card Anaesth. 2020 Oct-Dec;23(4):419-424. doi: 10.4103/aca.ACA_28_19.
The role of gender in the selection of the most effective method for treatment of patients with diffused coronary artery diseases remains a matter of debate. This study thus evaluated the effect of gender on long- and short-term outcomes of off-pump coronary endarterectomy (CE).
This was a single-center retrospective study of patients who had undergone coronary artery bypass graft (CABG). The patients were divided into two groups, the CABG and the CABG + CE group, and further stratified into male and female. Long-term survival for each group was estimated by Kaplan-Meier analysis with log-rank testing. In addition, Cox regression analyses of each gender were also carried out to identify the predictors of the primary and secondary endpoints.
Overall, 25.8% of the patients were female. Diseased vessels were not statistically different in the two groups - men and women. There was no significant difference in postoperative outcomes between males and females in the CABG and CABG + CE groups. There was no significant difference in hospital mortality in the two groups between males and females. Kaplan-Meier curves show that there was no significant difference in the 5-year cardiac mortality between males and females belonging to the CABG and CABG + CE groups.
The results of this study show that there was no significant difference in the short- and long-term outcomes of off-pump CABG and CE in both genders although women tend to carry a greater risk.
性别在选择治疗弥漫性冠状动脉疾病患者的最有效方法中的作用仍存在争议。本研究评估了性别对非体外循环冠状动脉内膜切除术（CE）的长期和短期结局的影响。
这是一项单中心回顾性研究，纳入了接受冠状动脉旁路移植术（CABG）的患者。患者分为 CABG 组和 CABG+CE 组，并进一步分为男性和女性。通过 Kaplan-Meier 分析和对数秩检验估计每组的长期生存情况。此外，还对每个性别进行了 Cox 回归分析，以确定主要和次要终点的预测因素。
总体而言，25.8%的患者为女性。两组（男性和女性）的病变血管无统计学差异。CABG 和 CABG+CE 组中，男性和女性的术后结果无显著差异。两组中，男性和女性的院内死亡率无显著差异。Kaplan-Meier 曲线显示，属于 CABG 和 CABG+CE 组的男性和女性的 5 年心脏死亡率无显著差异。
本研究结果表明，尽管女性风险较高，但非体外循环 CABG 和 CE 的短期和长期结局在两性之间无显著差异。
