Pharmacy College, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province, Key Laboratory Breeding Base of Co-founded by Sichuan Province and Ministry of Science and Technology, Chengdu 611137, China.
Pharmacy College, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province, Key Laboratory Breeding Base of Co-founded by Sichuan Province and Ministry of Science and Technology, Chengdu 611137, China.
Int J Biol Macromol. 2020 Dec 15;165(Pt B):2668-2683. doi: 10.1016/j.ijbiomac.2020.10.173. Epub 2020 Oct 25.
Plant polysaccharides with multiple biological activities and health benefit effects are usually considered as natural active macromolecules in food and medicine dual purposes plant. Nerveless, there are still some problems with plant polysaccharides, such as the lack of concentration in the range of action, poor stability, rapid blood clearance and poor targeting, which affect the bioavailability and clinical application of plant polysaccharides. Over the last decade, researchers have increasingly turned their attention toward understanding the role of plant polysaccharides in normal cellular function and in disease, while opening up new research fronts in designing and developing nanomaterial delivery systems for the treatment of cancer, immune diseases and other diseases using plant polysaccharides as a carrier or object drug. However, deficiencies of NDDS research limits the application of polysaccharides in disease treatment. Herein, advances in the application of plant polysaccharides in nano-based drug delivery systems are reviewed. In addition, the further research on plant polysaccharides in nanotechnology was prospected.
具有多种生物活性和保健功效的植物多糖通常被认为是兼具食品和医药双重功能的天然活性大分子。然而，植物多糖仍存在一些问题，如作用范围浓度不足、稳定性差、血液清除快、靶向性差等，影响了植物多糖的生物利用度和临床应用。在过去的十年中，研究人员越来越关注植物多糖在正常细胞功能和疾病中的作用，同时开辟了新的研究前沿，设计和开发纳米材料给药系统，以植物多糖作为载体或靶向药物治疗癌症、免疫性疾病等疾病。然而，NDDS 研究的不足限制了多糖在疾病治疗中的应用。本文综述了植物多糖在纳米药物传递系统中的应用进展。此外，还对植物多糖在纳米技术中的进一步研究进行了展望。
