Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.
Macromol Biosci. 2021 Sep;21(9):e2100162. doi: 10.1002/mabi.202100162. Epub 2021 Jun 18.
Inflammation is closely related to a variety of fatal or chronic diseases. Hence, targeting inflammation provides an alternative approach to improve the therapeutic outcome of diseases such as solid tumors, neurological diseases, and metabolic diseases. Polysaccharides are natural components with immune regulation, anti-virus, anti-cancer, anti-inflammation, and anti-oxidation activities. Herein, this review highlights recent progress in the polysaccharide-based drug delivery systems for achieving inflammation targeting and its related disease treatment. Moreover, the chemical modification and the construction of polysaccharide materials for drug delivery are discussed in detail.
炎症与多种致命或慢性疾病密切相关。因此，针对炎症提供了一种改善实体瘤、神经退行性疾病和代谢性疾病等疾病治疗效果的替代方法。多糖是具有免疫调节、抗病毒、抗癌、抗炎和抗氧化作用的天然成分。本文重点介绍了基于多糖的药物传递系统在实现炎症靶向及其相关疾病治疗方面的最新进展。此外，还详细讨论了用于药物传递的多糖材料的化学修饰和构建。
