Medical Parasitology Department, Faculty of Medicine, Benha University, Benha, Egypt.
Medical Parasitology Department, Faculty of Medicine, Helwan University, Cairo, Egypt.
Int J Nanomedicine. 2020 Oct 22;15:8167-8173. doi: 10.2147/IJN.S272532. eCollection 2020.
This study aims to assess the efficacy of silver nanoparticles (Ag Nps) alone and combined with metronidazole (Ag Nps + MTZ) as potential alternative therapeutic agents for .
The parasites were challenged with Ag Nps, Ag Nps + MTZ and MTZ. To assess the efficacy of drugs, counting of viable parasites was done after 1, 2, and 3 hours of adding the drugs.
count was reduced by 20.72%, 28.23%, and 18.92% after one hour of adding Ag Nps, Ag Nps + MTZ, and MTZ, respectively. Cysts count was further reduced by 51.49%, 61.61%, and 40.78% after 2 hours and by 71.69%, 79.67%, and 62.65% after 3 hours of adding the drugs in the same order, respectively.
There was a statistically significant difference (<0.05) in the in vitro growth inhibition of the parasite over the different time intervals when using the tested drugs against the control drug.
本研究旨在评估单独使用银纳米粒子（AgNps）和联合使用甲硝唑（AgNps+MTZ）作为. 的潜在替代治疗剂的疗效。
用 AgNps、AgNps+MTZ 和 MTZ 对寄生虫进行了挑战。为了评估药物的疗效，在添加药物后 1、2 和 3 小时，对活寄生虫进行计数。
加入 AgNps、AgNps+MTZ 和 MTZ 1 小时后，寄生虫数量分别减少了 20.72%、28.23%和 18.92%。加入药物 2 小时后，包囊数量分别减少了 51.49%、61.61%和 40.78%，加入药物 3 小时后，包囊数量分别减少了 71.69%、79.67%和 62.65%。
在不同的时间间隔内，用测试药物对抗对照药物时，寄生虫的体外生长抑制有统计学上的显著差异（<0.05）。
