Zhang Ping, Gong Jiahao, Jiang Yan, Long Yunfeng, Lei Weiqiang, Gao Xiuge, Guo Dawei
College of Animal Science and Food Engineering, Jinling Institute of Technology, 99 Hongjing Road, Nanjing 211169, China.
Engineering Center of Innovative Veterinary Drugs, MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, China.
Pharmaceutics. 2023 Jun 21;15(7):1783. doi: 10.3390/pharmaceutics15071783.
Silver nanoparticles (AgNPs) are ultra-small silver particles with a size from 1 to 100 nanometers. Unlike bulk silver, they have unique physical and chemical properties. Numerous studies have shown that AgNPs have beneficial biological effects on various diseases, including antibacterial, anti-inflammatory, antioxidant, antiparasitic, and antiviruses. One of the most well-known applications is in the field of antibacterial applications, where AgNPs have strong abilities to kill multi-drug resistant bacteria, making them a potential candidate as an antibacterial drug. Recently, AgNPs synthesized from plant extracts have exhibited outstanding antiparasitic effects, with a shorter duration of use and enhanced ability to inhibit parasite multiplication compared to traditional antiparasitic drugs. This review summarizes the types, characteristics, and the mechanism of action of AgNPs in anti-parasitism, mainly focusing on their effects in leishmaniasis, flukes, cryptosporidiosis, toxoplasmosis, , , and . The aim is to provide a reference for the application of AgNPs in the prevention and control of parasitic diseases.
银纳米颗粒（AgNPs）是尺寸在1到100纳米之间的超小银颗粒。与块状银不同，它们具有独特的物理和化学性质。大量研究表明，AgNPs对多种疾病具有有益的生物学效应，包括抗菌、抗炎、抗氧化、抗寄生虫和抗病毒。最著名的应用之一是在抗菌应用领域，AgNPs具有强大的杀灭多重耐药细菌的能力，使其成为一种潜在的抗菌药物候选物。最近，从植物提取物中合成的AgNPs表现出出色的抗寄生虫作用，与传统抗寄生虫药物相比，使用时间更短且抑制寄生虫繁殖的能力更强。本综述总结了AgNPs在抗寄生虫方面的类型、特性和作用机制，主要关注它们在利什曼病、吸虫病、隐孢子虫病、弓形虫病等方面的作用。目的是为AgNPs在寄生虫病防治中的应用提供参考。
