Zhang Li, Wang Mingliang, Liu Mingxia, Zhang Daoqiang
College of Computer Science and Technology, Nanjing Forestry University, Nanjing, China.
College of Computer Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing, China.
Front Neurosci. 2020 Oct 8;14:779. doi: 10.3389/fnins.2020.00779. eCollection 2020.
Deep learning has recently been used for the analysis of neuroimages, such as structural magnetic resonance imaging (MRI), functional MRI, and positron emission tomography (PET), and it has achieved significant performance improvements over traditional machine learning in computer-aided diagnosis of brain disorders. This paper reviews the applications of deep learning methods for neuroimaging-based brain disorder analysis. We first provide a comprehensive overview of deep learning techniques and popular network architectures by introducing various types of deep neural networks and recent developments. We then review deep learning methods for computer-aided analysis of four typical brain disorders, including Alzheimer's disease, Parkinson's disease, Autism spectrum disorder, and Schizophrenia, where the first two diseases are neurodegenerative disorders and the last two are neurodevelopmental and psychiatric disorders, respectively. More importantly, we discuss the limitations of existing studies and present possible future directions.
深度学习最近已被用于神经影像分析,如结构磁共振成像(MRI)、功能MRI和正电子发射断层扫描(PET),并且在脑疾病的计算机辅助诊断中,它相对于传统机器学习已实现了显著的性能提升。本文综述了深度学习方法在基于神经影像的脑疾病分析中的应用。我们首先通过介绍各种类型的深度神经网络及其最新进展,对深度学习技术和流行的网络架构进行全面概述。然后,我们综述了用于四种典型脑疾病计算机辅助分析的深度学习方法,这四种疾病包括阿尔茨海默病、帕金森病、自闭症谱系障碍和精神分裂症,其中前两种疾病是神经退行性疾病,后两种分别是神经发育和精神疾病。更重要的是,我们讨论了现有研究的局限性,并提出了可能的未来方向。