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本文引用的文献

1
Generation time-prolonging R plasmids: correlation between increases in the generation time of Escherichia coli caused by R plasmids and their molecular size.延长世代时间的R质粒：R质粒引起的大肠杆菌世代时间增加与其分子大小之间的相关性。
Plasmid. 1980 Jan;3(1):65-9. doi: 10.1016/s0147-619x(80)90034-7.
2
The maintenance of Plasmid-containing organisms in populations of Escherichia coli.含质粒的大肠杆菌群体的维持
J Gen Microbiol. 1981 Mar;123(1):129-41. doi: 10.1099/00221287-123-1-129.
3
Maintenance of some ColE1-type plasmids in chemostat culture.在恒化器培养中某些ColE1型质粒的维持
Mol Gen Genet. 1980;180(3):579-84. doi: 10.1007/BF00268063.
4
Partitioning of plasmid R1 in Escherichia coli. I. Kinetics of loss of plasmid derivatives deleted of the par region.质粒R1在大肠杆菌中的分配。I. 缺失par区域的质粒衍生物的丢失动力学。
Plasmid. 1980 Sep;4(2):215-27. doi: 10.1016/0147-619x(80)90011-6.
5
Two-step resistance by Escherichia coli B to bacteriophage T2.大肠杆菌B对噬菌体T2的两步抗性
Genetics. 1984 May;107(1):1-7. doi: 10.1093/genetics/107.1.1.
6
Selection in chemostats.恒化器中的选择
Microbiol Rev. 1983 Jun;47(2):150-68. doi: 10.1128/mr.47.2.150-168.1983.
7
Maintenance and genetic stability of vector plasmids pBR322 and pBR325 in Escherichia coli K12 strains grown in a chemostat.恒化器培养的大肠杆菌K12菌株中载体质粒pBR322和pBR325的维持及遗传稳定性
Mol Gen Genet. 1981;184(1):121-4. doi: 10.1007/BF00271207.
8
Cloning of replication, incompatibility, and stability functions of R plasmid NR1.R质粒NR1复制、不相容性及稳定性功能的克隆
J Bacteriol. 1980 Jan;141(1):87-99. doi: 10.1128/jb.141.1.87-99.1980.
9
Control of replication of bacterial plasmids: genetics, molecular biology, and physiology of the plasmid R1 system.细菌质粒复制的控制：质粒R1系统的遗传学、分子生物学及生理学
Plasmid. 1984 Sep;12(2):71-90. doi: 10.1016/0147-619x(84)90054-4.
10
Regulation of plasmid replication.质粒复制的调控
Microbiol Rev. 1984 Mar;48(1):1-23. doi: 10.1128/mr.48.1.1-23.1984.

分离和选择对大肠杆菌B中质粒pACYC184不稳定性的影响。

Effects of segregation and selection on instability of plasmid pACYC184 in Escherichia coli B.

作者信息

Lenski R E, Bouma J E

机构信息

Department of Ecology and Evolutionary Biology, University of California, Irvine 92717.

出版信息

J Bacteriol. 1987 Nov;169(11):5314-6. doi: 10.1128/jb.169.11.5314-5316.1987.

DOI:10.1128/jb.169.11.5314-5316.1987
PMID:3312174
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC213944/
Abstract

We use a mathematical model to analyze the dynamics of loss of nonconjugative pACYC184 from populations of Escherichia coli B in glucose-limited continuous culture. This model incorporates both plasmid segregation and selection against plasmid carriage. It is concluded that there is intense selection against plasmid carriage (s = 0.3 per culture generation), which amplifies the frequency of segregants arising de novo.

摘要

我们使用一个数学模型来分析在葡萄糖限制的连续培养中，大肠杆菌B群体中非接合型pACYC184质粒丢失的动态变化。该模型纳入了质粒分离和对携带质粒的选择作用。结果表明，存在针对携带质粒的强烈选择作用（每代培养的选择系数s = 0.3），这会增加从头产生的分离菌的频率。