分离和选择对大肠杆菌B中质粒pACYC184不稳定性的影响。
Effects of segregation and selection on instability of plasmid pACYC184 in Escherichia coli B.
作者信息
Lenski R E, Bouma J E
机构信息
Department of Ecology and Evolutionary Biology, University of California, Irvine 92717.
出版信息
J Bacteriol. 1987 Nov;169(11):5314-6. doi: 10.1128/jb.169.11.5314-5316.1987.
Abstract
We use a mathematical model to analyze the dynamics of loss of nonconjugative pACYC184 from populations of Escherichia coli B in glucose-limited continuous culture. This model incorporates both plasmid segregation and selection against plasmid carriage. It is concluded that there is intense selection against plasmid carriage (s = 0.3 per culture generation), which amplifies the frequency of segregants arising de novo.
摘要
我们使用一个数学模型来分析在葡萄糖限制的连续培养中，大肠杆菌B群体中非接合型pACYC184质粒丢失的动态变化。该模型纳入了质粒分离和对携带质粒的选择作用。结果表明，存在针对携带质粒的强烈选择作用（每代培养的选择系数s = 0.3），这会增加从头产生的分离菌的频率。
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