Department of Analytical Biochemistry, Institute of Food Technology and Nutrition, College of Natural Sciences, Rzeszow University, Zelwerowicza Street 4, 35-601 Rzeszów, Poland.
Department of Bioenergetics, Food Analysis and Microbiology, College of Natural Sciences, Rzeszow University, Zelwerowicza Street 4, 35-601 Rzeszów, Poland.
Oxid Med Cell Longev. 2020 Oct 13;2020:3534570. doi: 10.1155/2020/3534570. eCollection 2020.
Due to the progressive aging of the society, the prevalence and socioeconomic burden of neurodegenerative diseases are predicted to rise. The most common neurodegenerative disorders nowadays, such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis, can be classified as proteinopathies. They can be either synucleinopathies, amyloidopathies, tauopathies, or TDP-43-related proteinopathies; thus, nanoparticles with a potential ability to inhibit pathological protein aggregation and/or degrade already existing aggregates can be a promising approach in the treatment of neurodegenerative diseases. As it turns out, nanoparticles can be a double-edged sword; they can either promote or inhibit protein aggregation, depending on coating, shape, size, surface charge, and concentration. In this review, we aim to emphasize the need of a breakthrough in the treatment of neurodegenerative disorders and draw attention to nanomaterials, as they can also serve as a diagnostic tool for protein aggregates or can be used in a high-throughput screening for novel antiaggregative compounds.
由于社会的老龄化进程不断推进，预计神经退行性疾病的患病率和社会经济负担将会增加。如今最常见的神经退行性疾病，如帕金森病、阿尔茨海默病和肌萎缩侧索硬化症，可以归类为蛋白质病。它们可以是突触核蛋白病、淀粉样蛋白病、tau 蛋白病或 TDP-43 相关的蛋白质病；因此，具有抑制病理性蛋白质聚集和/或降解已存在聚集物的潜力的纳米粒子可能是治疗神经退行性疾病的一种有前途的方法。事实证明，纳米粒子可能是一把双刃剑；它们可以促进或抑制蛋白质聚集，具体取决于涂层、形状、大小、表面电荷和浓度。在这篇综述中，我们旨在强调需要在神经退行性疾病的治疗方面取得突破，并引起对纳米材料的关注，因为它们也可以作为蛋白质聚集物的诊断工具，或者可以用于高通量筛选新型抗聚集化合物。
