Gopinath Bamini, McMahon Catherine M, Lewis Joshua R, Bondonno Nicola P, Bondonno Catherine P, Burlutsky George, Hodgson Jonathan M, Mitchell Paul
Department of Linguistics, Macquarie University Hearing, Macquarie University, Balaclava Rd, Macquarie Park, NSW 2109, Australia.
Department of Ophthalmology and Westmead Institute for Medical Research, Centre for Vision Research, University of Sydney, Camperdown, NSW 2006, Australia.
Nutrients. 2020 Oct 28;12(11):3297. doi: 10.3390/nu12113297.
Dietary flavonoids are vasoactive phytochemicals with promising anti-inflammatory properties. We aimed to assess the associations between baseline intakes of six commonly consumed flavonoid subclasses and 10-year incidence of age-related hearing loss. At baseline, 1691 participants aged 50+ years had information on dietary intakes and hearing status. Hearing loss was defined as the pure-tone average of frequencies 0.5, 1.0, 2.0, and 4.0 kHz > 25 dB hearing level (HL). Dietary data were collected through a semi-quantitative food frequency questionnaire. The flavonoid content of foods was estimated using US databases. During the 10-year follow-up, 260 (31.6%) new cases of hearing loss (incident) were observed. After multivariable adjustment, participants in the fourth versus first quartile (reference group) of intake of dietary isoflavone had 36% lower risk of incident hearing loss after 10 years: odds ratios (OR) 0.64 (95% confidence intervals, CI, 0.42-0.99); = 0.03. Nonsignificant associations were observed between the other five flavonoid subclasses and 10-year incidence of hearing loss. Our findings do not support the hypothesis that the intake of dietary flavonoids protect against long-term risk of hearing loss. The association with isoflavone intake needs to be confirmed by other population-based studies.
膳食类黄酮是具有潜在抗炎特性的血管活性植物化学物质。我们旨在评估六种常见食用类黄酮亚类的基线摄入量与年龄相关性听力损失10年发病率之间的关联。在基线时，1691名年龄在50岁及以上的参与者提供了饮食摄入和听力状况信息。听力损失定义为0.5、1.0、2.0和4.0千赫兹频率的纯音平均听阈>25分贝听力水平（HL）。通过半定量食物频率问卷收集饮食数据。使用美国数据库估算食物中的类黄酮含量。在10年随访期间，观察到260例（31.6%）新的听力损失病例（发病）。经过多变量调整后，饮食异黄酮摄入量处于第四四分位数与第一四分位数（参照组）的参与者在10年后发生听力损失的风险降低了36%：优势比（OR）为0.64（95%置信区间，CI，0.42 - 0.99）；P = 0.03。在其他五类类黄酮亚类与10年听力损失发病率之间未观察到显著关联。我们的研究结果不支持膳食类黄酮摄入可预防听力损失长期风险的假设。与异黄酮摄入的关联需要其他基于人群的研究加以证实。
