Hong Sera, Purushothaman Baskaran, Song Joon Myong
College of Pharmacy, Seoul National University, Seoul 08826, Korea.
Antioxidants (Basel). 2020 Oct 28;9(11):1052. doi: 10.3390/antiox9111052.
Antioxidants are essential in regulating various physiological functions and oxidative deterioration. Over the past decades, many researchers have paid attention to antioxidants and studied the screening of antioxidants from natural products and their utilization for treatments in diverse pathological conditions. Nowadays, as printing technology progresses, its influence in the field of biomedicine is growing significantly. The printing technology has many advantages. Especially, the capability of designing sophisticated platforms is useful to detect antioxidants in various samples. The high flexibility of 3D printing technology is advantageous to create geometries for customized patient treatment. Recently, there has been increasing use of antioxidant materials for this purpose. This review provides a comprehensive overview of recent advances in printing technology-based assays to detect antioxidants and 3D printing-based antioxidant therapy in the field of tissue engineering. This review is divided into two sections. The first section highlights colorimetric assays using the inkjet-printing methods and electrochemical assays using screen-printing techniques for the determination of antioxidants. Alternative screen-printing techniques, such as xurography, roller-pen writing, stamp contact printing, and laser-scribing, are described. The second section summarizes the recent literature that reports antioxidant-based therapy using 3D printing in skin therapeutics, tissue mimetic 3D cultures, and bone tissue engineering.
抗氧化剂在调节各种生理功能和氧化损伤方面至关重要。在过去几十年中，许多研究人员关注抗氧化剂，并研究了从天然产物中筛选抗氧化剂及其在各种病理状况下的治疗应用。如今，随着印刷技术的进步，其在生物医学领域的影响正显著增强。印刷技术具有诸多优势。特别是，设计复杂平台的能力有助于检测各种样品中的抗氧化剂。3D打印技术的高灵活性有利于创建用于定制患者治疗的几何形状。最近，为此目的对抗氧化剂材料的使用越来越多。本综述全面概述了基于印刷技术的抗氧化剂检测方法以及组织工程领域基于3D打印的抗氧化剂治疗的最新进展。本综述分为两个部分。第一部分重点介绍使用喷墨打印方法的比色测定法以及使用丝网印刷技术测定抗氧化剂的电化学测定法。还描述了替代丝网印刷技术，如刻字印刷、滚笔书写、印章接触印刷和激光划刻。第二部分总结了最近报道在皮肤治疗、组织模拟3D培养和骨组织工程中使用3D打印进行基于抗氧化剂治疗的文献。
