Hallerbäck B, Solhaug J H, Carling L, Glise H, Hallgren T, Kagevi I, Svedberg L E, Wählby L
Dept. of Medicine and Surgery, Skövde Hospital, Sweden.
Scand J Gastroenterol. 1987 Sep;22(7):791-7. doi: 10.3109/00365528708991916.
The recurrence of peptic ulcer disease after successful treatment with 400 mg cimetidine twice daily or 1 g sucralfate four times daily was investigated in a double-blind, 1-year follow-up study. Endoscopy was performed if ulcer symptoms recurred and 2-4 and 9-11 months after endoscopically confirmed healing of the initial ulcer. No anti-ulcer medication was permitted during the follow-up period. The recurrence rates were 71% in the cimetidine group (n = 143) and 68% in the sucralfate group (n = 115) (p greater than 0.3). The rate of asymptomatic ulcer relapse was 26% in the cimetidine and 23% in the sucralfate group (p greater than 0.4). The time to relapse did not differ between the treatment groups (p greater than 0.3). In the cimetidine group smokers had a higher 12-month recurrence rate than non-smokers, 83% compared with 58% (p less than 0.01). The corresponding figures in the sucralfate group were 76% and 57% (p = 0.057). The median time to recurrence in the cimetidine-treated group was 17 weeks among smokers, compared to 43 weeks among non-smokers (p less than 0.001). In the sucralfate-treated group the median time to recurrence was 23 weeks among smokers and 32 weeks among non-smokers (p greater than 0.3). Pre-study use of non-steroidal anti-inflammatory drugs and the time to healing of the initial ulcer did not influence the relapse rates in either of the treatment groups.
在一项双盲、为期1年的随访研究中，对每日两次服用400毫克西咪替丁或每日四次服用1克硫糖铝成功治疗后消化性溃疡疾病的复发情况进行了调查。如果溃疡症状复发，以及在初次溃疡经内镜确认愈合后的2 - 4个月和9 - 11个月进行内镜检查。随访期间不允许使用抗溃疡药物。西咪替丁组（n = 143）的复发率为71%，硫糖铝组（n = 115）的复发率为68%（p大于0.3）。西咪替丁组无症状溃疡复发率为26%，硫糖铝组为23%（p大于0.4）。治疗组之间复发时间无差异（p大于0.3）。在西咪替丁组中，吸烟者12个月的复发率高于非吸烟者，分别为83%和58%（p小于0.01）。硫糖铝组的相应数字分别为76%和57%（p = 0.057）。西咪替丁治疗组中，吸烟者复发的中位时间为17周，而非吸烟者为43周（p小于0.001）。在硫糖铝治疗组中，吸烟者复发的中位时间为23周，非吸烟者为32周（p大于0.3）。研究前使用非甾体抗炎药以及初次溃疡的愈合时间对任何一个治疗组的复发率均无影响。
