关于平衡伤口愈合与无瘢痕皮肤修复的新见解。

New insights into balancing wound healing and scarless skin repair.

作者信息

Zhou Shengxi, Xie Mengbo, Su Jingjing, Cai Bingjie, Li Jingan, Zhang Kun

机构信息

School of Life Science, Zhengzhou University, Zhengzhou, Henan, P. R. China.

Department of Dermatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P. R. China.

出版信息

J Tissue Eng. 2023 Jul 27;14:20417314231185848. doi: 10.1177/20417314231185848. eCollection 2023 Jan-Dec.

DOI:10.1177/20417314231185848

PMID:37529248

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10388637/

Abstract

Scars caused by skin injuries after burns, wounds, abrasions and operations have serious physical and psychological effects on patients. In recent years, the research of scar free wound repair has been greatly expanded. However, understanding the complex mechanisms of wound healing, in which various cells, cytokines and mechanical force interact, is critical to developing a treatment that can achieve scarless wound healing. Therefore, this paper reviews the types of wounds, the mechanism of scar formation in the healing process, and the current research progress on the dual consideration of wound healing and scar prevention, and some strategies for the treatment of scar free wound repair.

摘要

烧伤、创伤、擦伤及手术后皮肤损伤所形成的瘢痕对患者的身体和心理都有严重影响。近年来，无瘢痕伤口修复的研究有了很大进展。然而，了解伤口愈合的复杂机制（其中各种细胞、细胞因子和机械力相互作用）对于开发能够实现无瘢痕伤口愈合的治疗方法至关重要。因此，本文综述了伤口的类型、愈合过程中瘢痕形成的机制、当前在兼顾伤口愈合与瘢痕预防方面的研究进展，以及一些无瘢痕伤口修复的治疗策略。