中性粒细胞迁移及中性粒细胞长时间接触对上皮通透性的影响。
The effect of neutrophil migration and prolonged neutrophil contact on epithelial permeability.
作者信息
Parsons P E, Sugahara K, Cott G R, Mason R J, Henson P M
机构信息
Department of Medicine, National Immunology and Respiratory Medicine, Denver, CO 80206.
出版信息
Am J Pathol. 1987 Nov;129(2):302-12.
Abstract
The effect of neutrophil migration and prolonged neutrophil contact on epithelial permeability was examined. Although neutrophil migration was not associated with a change in epithelial permeability, prolonged neutrophil-epithelial contact following migration resulted in an increase in epithelial permeability. These results were not altered by catalase, a specific neutrophil elastase inhibitor, methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl ketone or cyclohexamide. This suggests that neutrophil migration does not occur via an H2O2-induced reversible mechanism of junctional opening, which we describe herein.
摘要
研究了中性粒细胞迁移和中性粒细胞长时间接触对上皮通透性的影响。虽然中性粒细胞迁移与上皮通透性的变化无关，但迁移后中性粒细胞与上皮细胞的长时间接触导致上皮通透性增加。过氧化氢酶、一种特异性中性粒细胞弹性蛋白酶抑制剂、甲氧基琥珀酰 - 丙氨酸 - 丙氨酸 - 脯氨酸 - 缬氨酸 - 氯甲基酮或环己酰胺均未改变这些结果。这表明中性粒细胞迁移并非通过我们在此描述的H2O2诱导的连接开放可逆机制发生。
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本文引用的文献
1
Electron microscopic observations on the emigration of leucocytes.白细胞迁移的电子显微镜观察
Aust J Exp Biol Med Sci. 1961 Dec;39:609-23. doi: 10.1038/icb.1961.60.
2
The site of leucocyte emigration during inflammation.炎症过程中白细胞渗出的部位。
Q J Exp Physiol Cogn Med Sci. 1961 Apr;46:115-8. doi: 10.1113/expphysiol.1961.sp001522.
3
Electron micrographic observations on the emigration of leucocytes.白细胞迁移的电子显微镜观察
Q J Exp Physiol Cogn Med Sci. 1960 Oct;45:343-8. doi: 10.1113/expphysiol.1960.sp001489.
4
Occluding junctions in a cultured transporting epithelium: structural and functional heterogeneity.培养的转运上皮中的紧密连接：结构和功能的异质性
J Membr Biol. 1980 Mar 31;53(1):19-32. doi: 10.1007/BF01871169.
5
Oxidant injury of lung parenchymal cells.肺实质细胞的氧化损伤。
J Clin Invest. 1981 Nov;68(5):1277-88. doi: 10.1172/jci110374.
6
Transepithelial transport in cell culture: D-glucose transport by a pig kidney cell line (LLC-PK1).细胞培养中的跨上皮运输：猪肾细胞系（LLC-PK1）对D-葡萄糖的运输
J Membr Biol. 1981 Mar 15;59(1):13-8. doi: 10.1007/BF01870816.
7
Occluding junctions and cytoskeletal components in a cultured transporting epithelium.培养的转运上皮中的紧密连接和细胞骨架成分。
J Cell Biol. 1980 Dec;87(3 Pt 1):746-54. doi: 10.1083/jcb.87.3.746.
8
Reduction of the edema of acute hyperoxic lung injury by granulocyte depletion.通过粒细胞减少减轻急性高氧性肺损伤的水肿
J Appl Physiol Respir Environ Exerc Physiol. 1982 May;52(5):1237-44. doi: 10.1152/jappl.1982.52.5.1237.
9
Granulocytes mediate acute edematous lung injury in rabbits and in isolated rabbit lungs perfused with phorbol myristate acetate: role of oxygen radicals.粒细胞介导兔及用佛波醇肉豆蔻酸酯乙酸酯灌注的离体兔肺中的急性肺水肿性损伤：氧自由基的作用。
Am Rev Respir Dis. 1982 Apr;125(4):443-7. doi: 10.1164/arrd.1982.125.4.443.
10
Absence of inflammatory lung injury in rabbits challenged intravascularly with complement-derived chemotactic factors.用补体衍生趋化因子进行血管内攻击的家兔未出现炎症性肺损伤。
Am Rev Respir Dis. 1982 Mar;125(3):335-40. doi: 10.1164/arrd.1982.125.3.335.
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