中性粒细胞迁移及中性粒细胞长时间接触对上皮通透性的影响。
The effect of neutrophil migration and prolonged neutrophil contact on epithelial permeability.
作者信息
Parsons P E, Sugahara K, Cott G R, Mason R J, Henson P M
机构信息
Department of Medicine, National Immunology and Respiratory Medicine, Denver, CO 80206.
出版信息
Am J Pathol. 1987 Nov;129(2):302-12.
Abstract
The effect of neutrophil migration and prolonged neutrophil contact on epithelial permeability was examined. Although neutrophil migration was not associated with a change in epithelial permeability, prolonged neutrophil-epithelial contact following migration resulted in an increase in epithelial permeability. These results were not altered by catalase, a specific neutrophil elastase inhibitor, methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl ketone or cyclohexamide. This suggests that neutrophil migration does not occur via an H2O2-induced reversible mechanism of junctional opening, which we describe herein.
摘要
研究了中性粒细胞迁移和中性粒细胞长时间接触对上皮通透性的影响。虽然中性粒细胞迁移与上皮通透性的变化无关，但迁移后中性粒细胞与上皮细胞的长时间接触导致上皮通透性增加。过氧化氢酶、一种特异性中性粒细胞弹性蛋白酶抑制剂、甲氧基琥珀酰 - 丙氨酸 - 丙氨酸 - 脯氨酸 - 缬氨酸 - 氯甲基酮或环己酰胺均未改变这些结果。这表明中性粒细胞迁移并非通过我们在此描述的H2O2诱导的连接开放可逆机制发生。
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