姜黄素及其新制剂在妇科癌症中的治疗作用。
Therapeutic role of curcumin and its novel formulations in gynecological cancers.
机构信息
Halal Research Center of IRI, FDA, Tehran, Iran.
Department of Medical Biotechnology, Faculty of Medicine, Arak University of Medical Science, Arak, Iran.
出版信息
J Ovarian Res. 2020 Nov 4;13(1):130. doi: 10.1186/s13048-020-00731-7.
Abstract
Gynecological cancers are among the leading causes of cancer-associated mortality worldwide. While the number of cases are rising, current therapeutic approaches are not efficient enough. There are considerable side-effects as well as treatment resistant types. In addition, which all make the treatment complicated for afflicted cases. Therefore, in order to improve efficacy of the treatment process and patients' quality of life, searching for novel adjuvant treatments is highly warranted. Curcumin, a promising natural compound, is endowed with numerous therapeutic potentials including significant anticancer effects. Recently, various investigations have demonstrated the anticancer effects of curcumin and its novel analogues on gynecological cancers. Moreover, novel formulations of curcumin have resulted in further propitious effects. This review discusses these studies and highlights the possible underlying mechanisms of the observed effects.
摘要
妇科癌症是全球癌症相关死亡的主要原因之一。虽然病例数量在增加，但目前的治疗方法还不够有效。存在相当多的副作用和治疗耐药类型。此外，所有这些都使受影响的病例的治疗变得复杂。因此，为了提高治疗过程的疗效和患者的生活质量，寻找新的辅助治疗方法是非常必要的。姜黄素是一种很有前途的天然化合物，具有许多治疗潜力，包括显著的抗癌作用。最近，各种研究表明姜黄素及其新型类似物对妇科癌症具有抗癌作用。此外，姜黄素的新型制剂也产生了进一步的有利效果。本综述讨论了这些研究，并强调了观察到的效果的可能潜在机制。
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