Department of Health Sciences, Brock University, St. Catharines, ON, L2S 3A1, Canada.
Department of Health Sciences, Brock University, St. Catharines, ON, L2S 3A1, Canada; Centre for Bone and Muscle Health, Brock University, St. Catharines, ON, L2S 3A1, Canada.
Biomed Pharmacother. 2020 Nov;131:110717. doi: 10.1016/j.biopha.2020.110717. Epub 2020 Sep 23.
Prostate cancer is the most commonly diagnosed type of cancer in North American men and is typically classified as either androgen receptor positive or negative depending on the expression of the androgen receptor (AR). AR positive prostate cancer can be treated with hormone therapy while AR negative prostate cancer is aggressive and does not respond to hormone therapy. It has been previously reported that rosemary extract (RE) has antioxidant, anti-inflammatory and anti-cancer properties. In the present study, we found that treatment of the androgen-insensitive PC-3 prostate cancer cells with RE resulted in a significant inhibition of proliferation, survival, migration, Akt, and mTOR signaling. In addition, treatment of the androgen-sensitive 22RV1 prostate cancer cells with RE resulted in a significant inhibition of proliferation and survival while RE had no effect on normal prostate epithelial PNT1A cells. These findings suggest that RE has potent effects against prostate cancer and warrants further investigation.
前列腺癌是北美男性最常见的癌症类型，通常根据雄激素受体（AR）的表达分为 AR 阳性或阴性。AR 阳性前列腺癌可以用激素治疗，而 AR 阴性前列腺癌具有侵袭性，对激素治疗无反应。先前有报道称迷迭香提取物（RE）具有抗氧化、抗炎和抗癌特性。在本研究中，我们发现用 RE 处理雄激素不敏感的 PC-3 前列腺癌细胞导致增殖、存活、迁移、Akt 和 mTOR 信号显著抑制。此外，用 RE 处理雄激素敏感的 22RV1 前列腺癌细胞导致增殖和存活显著抑制，而 RE 对正常前列腺上皮 PNT1A 细胞没有影响。这些发现表明 RE 对前列腺癌具有强大的作用，值得进一步研究。
