Morbelli Silvia, Arnaldi Dario, Cella Eugenia, Raffa Stefano, Donegani Maria Isabella, Capitanio Selene, Massa Federico, Miceli Alberto, Filippi Laura, Chincarini Andrea, Nobili Flavio
Department of Health Science (DISSAL), University of Genoa, Genoa, Italy.
IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
EJNMMI Res. 2020 Nov 7;10(1):137. doi: 10.1186/s13550-020-00727-w.
Our aim was to compare a widely distributed commercial tool with an older free software (i) one another, (ii) with a clinical motor score, (iii) versus reading by experts.
We analyzed consecutive scans from one-hundred and fifty-one outpatients submitted to brain DAT SPECT for a suspected parkinsonism. Images were post-processed using a commercial (Datquant®) and a free (BasGanV2) software. Reading by expert was the gold standard. A subset of patients with pathological or borderline scan was evaluated with the clinical Unified Parkinson's Disease Rating Scale, motor part (MDS-UPDRS-III).
SBR, putamen-to-caudate (P/C) ratio, and both P and C asymmetries were highly correlated between the two software with Pearson's 'r' correlation coefficients ranging from .706 to .887. Correlation coefficients with the MDS-UPDRS III score were higher with caudate than with putamen SBR values with both software, and in general higher with BasGanV2 than with Datquant®. Datquant® correspondence with expert reading was 84.1% (94.0% by additionally considering the P/C ratio as a further index). BasGanV2 correspondence with expert reading was 80.8% (86.1% by additionally considering the P/C ratio).
Both Datquant® and BasGanV2 work reasonably well and similarly one another in semi-quantification of DAT SPECT. Both tools have their own strength and pitfalls that must be known in detail by users in order to obtain the best help in visual reading and reporting of DAT SPECT.
我们的目的是比较一种广泛使用的商业工具与一款较旧的免费软件，（i）两者之间进行比较，（ii）与临床运动评分进行比较，（iii）与专家解读进行比较。
我们分析了151例因疑似帕金森症接受脑部多巴胺转运体单光子发射计算机断层扫描（DAT SPECT）的门诊患者的连续扫描图像。图像使用一款商业软件（Datquant®）和一款免费软件（BasGanV2）进行后处理。专家解读为金标准。对一部分扫描结果为病理性或临界值的患者，使用临床统一帕金森病评定量表运动部分（MDS - UPDRS - III）进行评估。
两种软件之间，纹状体结合率（SBR）、壳核与尾状核比值（P/C）以及壳核和尾状核的不对称性均高度相关，皮尔逊相关系数“r”在0.706至0.887之间。两种软件中，尾状核SBR值与MDS - UPDRS III评分的相关系数均高于壳核SBR值，总体而言，BasGanV2的相关系数高于Datquant®。Datquant®与专家解读的一致性为84.1%（将P/C比值作为进一步指标时为94.0%）。BasGanV2与专家解读的一致性为80.8%（将P/C比值作为进一步指标时为86.1%）。
在DAT SPECT的半定量分析中，Datquant®和BasGanV2的表现都相当不错，且二者表现相似。两种工具都有其自身的优势和缺陷，用户必须详细了解，以便在DAT SPECT的视觉解读和报告中获得最佳帮助。
