Kankala Ranjith Kumar, Wang Shi-Bin, Chen Ai-Zheng
College of Chemical Engineering, Huaqiao University, Xiamen, Fujian 361021, P. R. China.
Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen, Fujian 361021, P. R. China.
iScience. 2020 Oct 17;23(11):101687. doi: 10.1016/j.isci.2020.101687. eCollection 2020 Nov 20.
Owing to their attractive physicochemical and morphological attributes, mesoporous silica nanoparticles (MSNs) have attracted increasing attention over the past two decades for their utilization in diversified fields. Despite the success, these highly stable siliceous frameworks often suffer from several shortcomings of compatibility issues, uncontrollable degradability leading to long-term retention , and substantial unpredictable toxicity risks, as well as deprived drug encapsulation efficiency, which could limit their applicability in medicine. Along this line, various advancements have been made in re-engineering the stable siliceous frameworks, such as the incorporation of diverse molecular organic, as well as inorganic (cationic and anionic) species and monitoring the processing, as well as formulation parameters, resulting in the hetero-nanostructures of irregular-shaped (Janus and multi-podal) and dynamically-modulated (deformable solids) architectures with high morphological complexity. Insightfully, this review gives a brief emphasis on re-engineering such stable siliceous frameworks through modifying their intrinsic structural and physicochemical attributes. In conclusion, we recapitulate the review with exciting perspectives.
由于其具有吸引人的物理化学和形态学特性，在过去二十年中，介孔二氧化硅纳米颗粒（MSNs）因其在多个领域的应用而受到越来越多的关注。尽管取得了成功，但这些高度稳定的硅质框架往往存在几个缺点，如兼容性问题、不可控的降解性导致长期留存、大量不可预测的毒性风险，以及药物包封效率低下，这些都可能限制它们在医学上的应用。沿着这条线，在对稳定的硅质框架进行重新设计方面已经取得了各种进展，例如引入各种分子有机以及无机（阳离子和阴离子）物种，并监测加工以及配方参数，从而产生具有高形态复杂性的不规则形状（双面和多足）和动态调制（可变形固体）结构的异质纳米结构。有见地的是，本综述简要强调了通过修改其内在结构和物理化学特性来重新设计这种稳定的硅质框架。总之，我们以令人兴奋的观点总结了本综述。
