Prilepskii Artur Y, Serov Nikita S, Kladko Daniil V, Vinogradov Vladimir V
International Institute "Solution Chemistry of Advanced Materials and Technologies", ITMO University, 191002 Saint Petersburg, Russia.
Pharmaceutics. 2020 Nov 5;12(11):1056. doi: 10.3390/pharmaceutics12111056.
Atherosclerosis, being an inflammation-associated disease, represents a considerable healthcare problem. Its origin remains poorly understood, and at the same time, it is associated with extensive morbidity and mortality worldwide due to myocardial infarctions and strokes. Unfortunately, drugs are unable to effectively prevent plaque formation. Systemic administration of pharmaceuticals for the inhibition of plaque destabilization bears the risk of adverse effects. At present, nanoscience and, in particular, nanomedicine has made significant progress in both imaging and treatment of atherosclerosis. In this review, we focus on recent advances in this area, discussing subjects such as nanocarriers-based drug targeting principles, approaches towards the treatment of atherosclerosis, utilization of theranostic agents, and future prospects of nanoformulated therapeutics against atherosclerosis and inflammatory diseases. The focus is placed on articles published since 2015 with additional attention to research completed in 2019-2020.
动脉粥样硬化作为一种与炎症相关的疾病，是一个相当严重的医疗保健问题。其发病原因仍知之甚少，与此同时，由于心肌梗死和中风，它在全球范围内导致了广泛的发病和死亡。不幸的是，药物无法有效预防斑块形成。全身性给药抑制斑块不稳定存在不良反应风险。目前，纳米科学，尤其是纳米医学在动脉粥样硬化的成像和治疗方面都取得了重大进展。在这篇综述中，我们关注该领域的最新进展，讨论基于纳米载体的药物靶向原理、动脉粥样硬化治疗方法、诊疗剂的应用以及纳米制剂治疗动脉粥样硬化和炎症性疾病的未来前景等主题。重点关注2015年以来发表的文章，并特别关注2019 - 2020年完成的研究。
