Ilyas R A, Zuhri M Y M, Norrrahim Mohd Nor Faiz, Misenan Muhammad Syukri Mohamad, Jenol Mohd Azwan, Samsudin Sani Amril, Nurazzi N M, Asyraf M R M, Supian A B M, Bangar Sneh Punia, Nadlene R, Sharma Shubham, Omran Abdoulhdi A Borhana
School of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia (UTM), Johor Bahru 81310, Johor, Malaysia.
Centre for Advanced Composite Materials (CACM), Universiti Teknologi Malaysia (UTM), Johor Bahru 81310, Johor, Malaysia.
Polymers (Basel). 2022 Jan 3;14(1):182. doi: 10.3390/polym14010182.
Recent developments within the topic of biomaterials has taken hold of researchers due to the mounting concern of current environmental pollution as well as scarcity resources. Amongst all compatible biomaterials, polycaprolactone (PCL) is deemed to be a great potential biomaterial, especially to the tissue engineering sector, due to its advantages, including its biocompatibility and low bioactivity exhibition. The commercialization of PCL is deemed as infant technology despite of all its advantages. This contributed to the disadvantages of PCL, including expensive, toxic, and complex. Therefore, the shift towards the utilization of PCL as an alternative biomaterial in the development of biocomposites has been exponentially increased in recent years. PCL-based biocomposites are unique and versatile technology equipped with several importance features. In addition, the understanding on the properties of PCL and its blend is vital as it is influenced by the application of biocomposites. The superior characteristics of PCL-based green and hybrid biocomposites has expanded their applications, such as in the biomedical field, as well as in tissue engineering and medical implants. Thus, this review is aimed to critically discuss the characteristics of PCL-based biocomposites, which cover each mechanical and thermal properties and their importance towards several applications. The emergence of nanomaterials as reinforcement agent in PCL-based biocomposites was also a tackled issue within this review. On the whole, recent developments of PCL as a potential biomaterial in recent applications is reviewed.
由于当前环境污染问题日益严重以及资源稀缺，生物材料这一主题的最新进展引起了研究人员的关注。在所有相容性生物材料中，聚己内酯（PCL）因其具有生物相容性和低生物活性等优点，被认为是一种极具潜力的生物材料，尤其在组织工程领域。尽管PCL具有诸多优点，但其商业化仍被视为一项新兴技术。这导致了PCL存在一些缺点，包括价格昂贵、有毒且生产过程复杂。因此，近年来在生物复合材料开发中使用PCL作为替代生物材料的转变呈指数级增长。基于PCL的生物复合材料是一种独特且用途广泛的技术，具有多个重要特性。此外，了解PCL及其共混物的性能至关重要，因为这会受到生物复合材料应用的影响。基于PCL的绿色和杂化生物复合材料的卓越特性拓展了它们的应用范围，例如在生物医学领域、组织工程和医疗植入物方面。因此，本综述旨在批判性地讨论基于PCL的生物复合材料的特性，包括其力学和热性能以及它们对多种应用的重要性。本综述还探讨了纳米材料作为基于PCL的生物复合材料增强剂的出现情况。总体而言，本文综述了PCL作为一种潜在生物材料在近期应用中的最新进展。
