Biotechnology Research Center, Shandong Academy of Agricultural Sciences, Jinan, China.
College of Animal Sciences and Technology, Henan Agricultural University, Zhengzhou, China.
Sci Rep. 2020 Nov 10;10(1):19476. doi: 10.1038/s41598-020-75207-1.
High-throughput farming of animals for an essential purpose such as large scale health and production of hogs is a challenge for the food industry in the modern world. The problem is that the breeding of livestock for fast growth or high yields of meat is often associated with illness and microbial infection that develop under the breeding conditions. Piglet diarrhea is most common pig disease, leading to heavy mortality and thereby economic loss. We proved that chemical drugs can relieve the symptoms of diarrhea in ill piglets, but they do not treat the underlying cause, i.e. significantly altered bacterial gut flora. Using Illumina sequencing of fecal DNA, we showed that the bacterial gut flora of piglets treated with antibiotics remain close to the ill conditions. However, using Illumina sequencing of fecal DNA from piglets treated with a specific Bacillus (Bacillus subtilis Y-15, B. amyloliquefaciens DN6502 and B. licheniformis SDZD02) demonstrated the efficiency of natural bioproducts not only on curing diarrhea, but also on beneficial bacteria to re-establish in the piglet gut. We therefore propose a new natural "medicine" to be explored by the world farm animal agriculture industry, particularly for sustainable improvement of swine livestock production and health.
为了实现大规模健康养殖和生产等重要目标，对现代食品行业而言，进行动物的高通量养殖是一项挑战。问题在于，为了实现快速生长或提高肉类产量而对牲畜进行的养殖，往往会导致疾病和微生物感染，而这些疾病和微生物感染是在养殖条件下产生的。仔猪腹泻是最常见的猪病，会导致高死亡率，从而造成经济损失。我们已经证明，化学药物可以缓解患病仔猪的腹泻症状，但它们并不能治疗根本原因，即肠道细菌菌群的显著改变。通过对粪便 DNA 进行 Illumina 测序，我们发现接受抗生素治疗的仔猪的肠道细菌菌群仍然接近患病状态。然而，通过对接受特定芽孢杆菌（枯草芽孢杆菌 Y-15、解淀粉芽孢杆菌 DN6502 和地衣芽孢杆菌 SDZD02）治疗的仔猪的粪便 DNA 进行 Illumina 测序，我们证明了天然生物制品的有效性不仅在于治疗腹泻，还有助于有益细菌在仔猪肠道中重新建立。因此，我们提出了一种新的天然“药物”，供世界畜牧业探索，特别是用于可持续提高猪的养殖生产和健康水平。
